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Scientists discover receptor that blocks Covid-19 infection

sydney.edu.au

21–30 of 167 posts

Re: Scientists discover receptor that blocks Covid-19 infection

#21
post #19

Earlier quoted context omitted.

Isolating and denying effective schooling to every kid who comes down with a one-day mild illness for ten days does not seem like a risk-proportionate response to me.

Why not? I don't think skipping one week and a half of school when you're 8 will have any real effect in your life neither in the short or long term future. Meanwhile, if they get in contact with someone with some sort of immunodeficiency along the way it could cause irreparable damage.

> one week and a half of school when you're 8

I think you're vastly underestimating how often kids exhibit symptoms potentially consistent with Covid during a school year.

Re: Scientists discover receptor that blocks Covid-19 infection

#22

Very interesting, according to the authors it’s “like velcro”. > [Covid] primarily uses a protein called the angiotensin-converting enzyme 2 (ACE2) receptor to enter human cells. Lung cells have high levels of ACE2 receptors, which is why the COVID-19 virus often causes severe problems in this organ of infected people. > Like ACE2, LRRC15 is a receptor for coronavirus, meaning the virus can bind to it. But unlike ACE…

I’ve seen the spikes mentioned a lot. Are these mechanical descriptions of how the spikes operate dumbed down for the average person to understand? Im surprised we don’t hear more about biologically destroying the cells instead.

My background on this comes from a neuroscience course in gradschool. The idea is that molecules and proteins “bind” to receptors which cause a cascade of reactions. The binding depends on the shape of the proteins and receptors.

A bridge like protein is created by removing parts of the spike protein through the cascade. The bridge connects the virus and the cell, and folds into itself to cause the two cells to merge.

https://youtu.be/Xuc9D4LVJdg

I am not sure why it is called spike but I’d guess it’s because it looks like tiny spikes on the virus.

So when what we do with mRNA vaccines is produce the mRNA that encodes this protein, and wrap it in lipids which allow it to enter the cells and the cells manufacture it.

Now, our cells don’t naturally produce the spike protein, so this triggers our immune system to build antibodies which bind onto the proteins and render them useless, or flags for certain parts of our immune system. This results in increased production of certain cells and proteins for this specific protein.

Our immune system has the capacity to create antibodies for and bind onto all sorts of different proteins. This is because it the immune system is allowed to recombine and order its DNA. In order to avoid wrecking havoc at our own body, the immune system passes through filters which filter out proteins that would bind to the naturally occurring proteins in our body.

Re: Scientists discover receptor that blocks Covid-19 infection

#23

Very interesting, according to the authors it’s “like velcro”. > [Covid] primarily uses a protein called the angiotensin-converting enzyme 2 (ACE2) receptor to enter human cells. Lung cells have high levels of ACE2 receptors, which is why the COVID-19 virus often causes severe problems in this organ of infected people. > Like ACE2, LRRC15 is a receptor for coronavirus, meaning the virus can bind to it. But unlike ACE…

I’ve seen the spikes mentioned a lot. Are these mechanical descriptions of how the spikes operate dumbed down for the average person to understand? Im surprised we don’t hear more about biologically destroying the cells instead.

No, coronavirus and many other viruses have spike proteins, that look a bit like spikes[0].

[0]: https://en.m.wikipedia.org/wiki/Spike_protein

Re: Scientists discover receptor that blocks Covid-19 infection

#24

To me the more interesting aspect of this research is the possibility to test susceptibility to severe infection. If you know ahead of time you are high risk, then the treatment and behavior is different than someone who knows they are low risk. Right now we treat everything the same - recommend everyone is vaccinated and everyone wear masks during outbreaks. I’d really like to know how at risk I am, and act accordin…

[dead]

Re: Scientists discover receptor that blocks Covid-19 infection

#25
post #19

Earlier quoted context omitted.

Isolating and denying effective schooling to every kid who comes down with a one-day mild illness for ten days does not seem like a risk-proportionate response to me.

Why not? I don't think skipping one week and a half of school when you're 8 will have any real effect in your life neither in the short or long term future. Meanwhile, if they get in contact with someone with some sort of immunodeficiency along the way it could cause irreparable damage.

I think kids are likely to catch asymptomatic or extremely mild Covid annually. That’ll potentially be 4-5% of their educational time.

Kids of wealthy families with parents with flexible jobs will be fine. Not every kid is in a home situation like that.

Re: Scientists discover receptor that blocks Covid-19 infection

#26
post #19

Earlier quoted context omitted.

Why not? I don't think skipping one week and a half of school when you're 8 will have any real effect in your life neither in the short or long term future. Meanwhile, if they get in contact with someone with some sort of immunodeficiency along the way it could cause irreparable damage.

> one week and a half of school when you're 8 I think you're vastly underestimating how often kids exhibit symptoms potentially consistent with Covid during a school year.

How often do they exhibit symptoms AND trigger a PCR test?

Re: Scientists discover receptor that blocks Covid-19 infection

#27

Very interesting, according to the authors it’s “like velcro”. > [Covid] primarily uses a protein called the angiotensin-converting enzyme 2 (ACE2) receptor to enter human cells. Lung cells have high levels of ACE2 receptors, which is why the COVID-19 virus often causes severe problems in this organ of infected people. > Like ACE2, LRRC15 is a receptor for coronavirus, meaning the virus can bind to it. But unlike ACE…

I’ve seen the spikes mentioned a lot. Are these mechanical descriptions of how the spikes operate dumbed down for the average person to understand? Im surprised we don’t hear more about biologically destroying the cells instead.

It isn't entirely understood, but the actual shapes of the molecules matter, so there is at least some mechanical analogy.

Re: Scientists discover receptor that blocks Covid-19 infection

#29
post #19

Earlier quoted context omitted.

Isolating and denying effective schooling to every kid who comes down with a one-day mild illness for ten days does not seem like a risk-proportionate response to me.

Why not? I don't think skipping one week and a half of school when you're 8 will have any real effect in your life neither in the short or long term future. Meanwhile, if they get in contact with someone with some sort of immunodeficiency along the way it could cause irreparable damage.

> Meanwhile, if they get in contact with someone with some sort of immunodeficiency along the way it could cause irreparable damage.

Is there any evidence this is different for Covid-19 than the vast sea of other viruses kids catch but we don’t PCR test for?

Re: Scientists discover receptor that blocks Covid-19 infection

#30
post #19

Earlier quoted context omitted.

Why not? I don't think skipping one week and a half of school when you're 8 will have any real effect in your life neither in the short or long term future. Meanwhile, if they get in contact with someone with some sort of immunodeficiency along the way it could cause irreparable damage.

> Meanwhile, if they get in contact with someone with some sort of immunodeficiency along the way it could cause irreparable damage. Is there any evidence this is different for Covid-19 than the vast sea of other viruses kids catch but we don’t PCR test for?

Probably not. It's likely there are worse diseases out there that we just don't check and keep our normal lives being carriers. But once you know, it's probably better to avoid. I think questioning whether or not doing a pcr test is good use of resources. But I don't think skipping school for a few days is where the problem resides.
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