Harvard, don't lock in your content! Other courses in many formats are available on http://www.extension.harvard.edu/open-learning-initiative Why should this one be iTunes only?
1. It's not in a proprietary format, the documents are PDF, the videos are AAC/H264. (I give up the h264 debate for today). Having to run iTunes to access the store is hardly "lock in". You might as well suggest turning on your computer is lock in.
2. This is on a CDN managed externally, Harvard don't need to invest in data centers.
3. Harvard don't have to pay for hosting/transmission/upkeep costs.
4. It enables harvard to provide something for free when normally they'd need to allocate budget. (And with that possibly charge for it.)
5. It's part of iTunes U, which is praised by universities across the globe for being an excellent enabler of education.