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Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

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141–150 of 168 posts

Re: Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

#141

I mean, that's kind of the gist of supplements as a whole, you only take them if you cannot replicate it using a normal diet/lifestyle. The biggest example for this IMO is Vitamin D. If you can spend time in the Sun regularly every day, you won't ever need to touch vitamin D. But how realistic is that for most people ? The only supplement I've encountered so far that has a noticeable effect that cannot be reproduced…

Creatine...would say especially if you're male, is such a game-changer. Recently got my dad who is in his 70s to start taking it and it's been enormously positive for him. Really good stuff. Personally think it's probably equally valuable for women but can't get my wife to take it (worried about the bloating which is a thing). To your point it would be very difficult to get the equivalent creatine from your diet. Wou…

I lift weights and do other exercise but never took Creatine. Are there benefits that aren't tied to exercise performance specifically as a goal ?

Does it have downsides in the body?

Re: Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

#142

Earlier quoted context omitted.

Yes. Had tons of random problems. Ended up being autoimmune Sjogrens and a clotting disorder. Diet changes and supplements are how I got thing under control for most issues. Blood thinners for Clotting since That’s way to dangerous, and no combination of anything else helped. LDN covers symptoms when I’m not strict about diet.

Interesting. I had similar symptoms like migraine/brain fog, stiff neck and muscle tension as soon as October (winter in Central Europe) came. Tested for Vitamin D deficiency and had super low levels. Since taking supplements I feel good in winter for the first time in probably 5 years. I'm also a very outdoorsy person, so getting enough sun is not always a sure way wo have high levels of Vitamin D.

Look up IIH. High cranial pressure. Comment about stiff neck is a big clue.

Re: Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

#143
post #11

Earlier quoted context omitted.

I guess the argument would be that you don't know for sure whether your diet does provide all the nutrients your body needs, so supplements could be used to fill in any gaps. The assumption being that your body will just dispose of any excess safely.

There is also the triage theory of aging where the idea is that when micronutrient levels are low (not low enough to cause acute symptoms but below the recommended daily allowance), they are triaged and used where needed (such as ATP production) at the expense of being used normally. The theory is that this can cause long-term problems such as neural decay, cancer, and other signs of aging. https://www.ncbi.nlm.nih.g…

+1 for Bruce Ames. This idea profoundly shaped my thinking a few years ago.

The one nit is I'm not sure how we'd go about testing it.

Re: Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

#144

Earlier quoted context omitted.

You you can just buy cold pressed flax oil and supplement with that. ~30 USD for ~1L iirc and it has an absolute assload of ALA (omega3) Hemp seed oil is a good one for omega6 but usually people get enough 6 from diet and 3 is the one we need to boost to get the 3:6 ratio up https://en.m.wikipedia.org/wiki/Fatty_acid_ratio_in_food

ALA must be converted to EPA and DHA, which it does at less than 10% efficiency, so you'd need to consume an assload of it, too. Your best bet is still fish(oil).

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Re: Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

#145

Earlier quoted context omitted.

You you can just buy cold pressed flax oil and supplement with that. ~30 USD for ~1L iirc and it has an absolute assload of ALA (omega3) Hemp seed oil is a good one for omega6 but usually people get enough 6 from diet and 3 is the one we need to boost to get the 3:6 ratio up https://en.m.wikipedia.org/wiki/Fatty_acid_ratio_in_food

ALA must be converted to EPA and DHA, which it does at less than 10% efficiency, so you'd need to consume an assload of it, too. Your best bet is still fish(oil).

and you can actually use up all the various desaturase and elongase enzymes in the process so that 10% upper bound drops markedly as you consume more ALA. Put differently long chain n-3's production definitely isn't linearly dependent on short chain n-3s like ALA and stearidonic acid.

Re: Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

#147
post #128

Earlier quoted context omitted.

> anyone who has looked into the evidence around nootropics can tell you that pretty much nobody wants to study that There's a class of areas where lots of non-experts are interested, but doing studies large enough to detect modest effect sizes with high confidence is too expensive. Nutrition can do either large survey studies, or small controlled experiments. Exercise researchers often have to work with a small numb…

> I feel like the hardest parts are getting participants to adhere to their assigned intervention, and preventing participants with a pre-existing agenda from joining. This combined with perverse incentives are why it's not possible. Non-experts with the resources to solve these problems are generally trying to sell you something, and aren't particularly interested in the truth.

Perhaps so. Saying it's "not possible" seems like an overly strong conclusion.

For specific interventions, I think it might be possible to have open, blinded participation. E.g. for supplements which may affect memory:

- Participants sign up to buy a supplement which they know will be one of k generally safe supplements or a placebo

- The specific supplement or placebo they receive it thompson sampled (or similar) from our bandit given data so far, and sent to them unlabeled

- They're only able to receive their next bottle if they complete weekly tests or measurements

The value prop is that you're probably buying a pretty good intervention, even if you don't know which one it is (and perhaps you're getting a discount subsidized by the minority of people who are paying for a placebo at any given time).

For a number of questions related to exercise, people may fall into camps about their prior beliefs, and may self-sabotage if they're in treatment group that goes against their preferences but there isn't a clear thing to sell. E.g. which of a family of training schedules helps people reduce their 10k running time the most?

Re: Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

#148

Earlier quoted context omitted.

Your sort of correct. Lots of drugs like plaquninal are immune modifiers not suppressant. However shoving large amounts of sugar and basically everything in the American diet is a great way to get the immune system to decide that everything in body is the enemy.

Sugar is pro-inflammatory, and so is omega-6 fatty acids, the consumption of both of which has increased massively within the last 60-70 years. Omega-6 fats have gone from less than 5% of human diet to up to 30% today, thanks to the commercial success of 'vegetable' oils. These two alone probably represent the most conspicuous diet changes that have happened in our societies in recent history and should be obvious su…

The biggest change in the human diet is the explosion of cheap calories on the food market, especially hyper palatable ones.

If canola oil or even just linoleic acid were so bad for us, we could cause worse health outcomes by intervening them into diets, but that’s not what happens in RCTs.

Re: Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

#149
Anecdotal evidence time!

I take 3 high strength omega 3 tablets every day. I feel like it sharpens my mind and improves my focus. It might be a placebo but I know when I go off them (sometimes I have a few off months for no real reason) I get bad brain fog and my performance at work slips. With omegas i feel like I sleep better and recover from the gym quicker

Re: Omega-3s: Are “Brain-Boosting” Effects Scientifically Backed?

#150

Anecdotally, I've read a long time ago that fish oil should help with sleep but I didn't start supplementing. Fast forward to this summer, I had big sleep problems, I couldn't keep a normal schedule and when I woke up I had terrible brain fog, took my like 2-3h in the morning to wake up properly and be able to function. Then I started taking fish oil, I got it by the bottle because I've read pills could have rancid o…

What brand/product did you buy?
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