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Ask HN: What have you created that deserves a second chance on HN?

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Re: Ask HN: What have you created that deserves a second chance on HN?

#41

Post by JPLeRouzic »

A few years ago (~2017) I created a tool in the biomedical domain to design peptide vaccines.

https://www.padiracinnovation.org/en/peptide_PoC/

Peptide vaccines are not very efficient, but they can be easily designed to address a large number of diseases. Basically I would like that a pharmacist could use this tool with just 2 days training.

How it works? If you know that a certain protein is produced by a certain type of malign cell and only by those cells, a peptide vaccine will cause the human immune system to try to eliminate the cells that produce that protein.

The most obvious use is in the case of some cancers cells which produce a certain protein. These proteins are named "tumor specific antigen". It is an antigenic substance which is produced only by tumor cells. Tumor antigens are useful tumor markers in identifying tumor cells that are targeted by the immune system when it is primed by a peptide vaccine.

Another interesting thing is that cancerous cells evolves quickly to try to evade therapies, here it's very easy to design a new peptide vaccine, for example every week.

As the name hints at, it's a proof of concept, I designed several variations. A good thing is that you don't need a lot of CPU power to run it. I use a cheap VPS from OVH.

I have written a large documentation here:

https://www.padiracinnovation.org/en/peptide_PoC/doc/documen...

(Access is limited to one per day per IP)

Re: Ask HN: What have you created that deserves a second chance on HN?

#42

Post by cactuscooler1 »

Good thread to see what other devs here are building!

https://collabmatch.io/

Working on this: a way for newsletters and blogs to grow through cross promos.

One of the hardest things imo for blogs/newsletters is getting more viewers over time. Was particularly hard for my Rust blog. I've been growing it fast through cross collabs, hence making this

If anyone's got a blog or newsletter they would like to grow faster, check it out. Happy to answer questions too

Re: Ask HN: What have you created that deserves a second chance on HN?

#45

Post by untech »

cc101 wrote: post #38

https://apps.apple.com/us/app/epiphany-workflow-ii/id1508000... ADHD is a problem for many people in high tech. Epiphany Workflow is a mac program for very bright college students who are in academic trouble caused by ADHD. E provides help organizing and sustaining a directed academic effort. It's particularly good for organizing research papers and compiling class notes into a study guide.

I didn’t tried your app yet, but I think your idea is great, and that this niche is underexploited.

I hope you won’t mind a little feedback. There is one screenshot on the app page, it looks fine in general, but I was a bit frustrated by the center-aligned text. Because of alignment, it was hard to read.

Wish you luck!

Re: Ask HN: What have you created that deserves a second chance on HN?

#46

Post by donatj »

It's not 100% done yet - the rough MVP functionality is in place - but I'd love to know what people think

https://shielded.dev/

Simple API controlled README "shields". Lets you update a custom badge by API - fully open source.

Lets you update the badges to say whatever you want as part of your CI process. For instance we have it show the number of build warnings the most recent build generated.

Example badge:

https://img.shielded.dev/s/c74

and example API call

    curl -X "POST" "https://api.shielded.dev" \
     -H 'Authorization: token ' \
     -H 'Content-Type: application/x-www-form-urlencoded; charset=utf-8' \
     --data-urlencode 'title=Build Warnings' \
     --data-urlencode 'text=5' \
     --data-urlencode 'color=5041be'

Re: Ask HN: What have you created that deserves a second chance on HN?

#47

Post by cvhashim04 »

pgjones wrote: post #37

I've three things :), 1. Quart, https://quart.palletsprojects.com , an ASGI (async/await) re-implementation of the Python web MicroFramework Flask. It is now maintained alongside, by the same people, as Flask. 2. Hypercorn, https://hypercorn.readthedocs.io , an ASGI/WSGI server that supports HTTP/1, HTTP/2, and HTTP/3. 3. My book "A Blueprint for Production-Ready Web Applications", which uses both of the above and sh…

Very nice ^^

Re: Ask HN: What have you created that deserves a second chance on HN?

#48

Post by willmeyers »

vitejose wrote: post #14
willmeyers wrote: post #8

I made https://welovefreemovies.com It's a showcase of movies that people made and released for free on YouTube (my original submission has better details). I'm pretty sure it got hit by the auto spam filter due to the name. OG submission if you're interested: https://news.ycombinator.com/item?id=34288257

What are the criteria for inclusion?

If you make a movie (>40min) independently and share it on YouTube and Letterboxd and I find I'd probably add it so long as it looks like you actually tried to make something.

I don't really care if the movie is "good". The people who made and shared them clearly put a lot of work into them and were brave enough to share their art on the internet so to me I feel they deserve some nice showcase

I setup an email will@welovefreemovies.com too if you want to send me something directly

Re: Ask HN: What have you created that deserves a second chance on HN?

#49

Post by scrapcode »

mike_hearn wrote: post #44

Does anyone know why there are so many dead posts on /shownew? Maybe a fifth of all posts end up dead for no obvious reason. They seem just like any other Show HN thread, and nothing is clearly wrong with the posting accounts either.

"The post was killed by software, user flags, or moderators. [...] If you see a [dead] post that shouldn't be dead, you can vouch for it. Click on its timestamp to go to its page, then click 'vouch' at the top. When enough users do this, the post is restored. There's a small karma threshold before vouch links appear." [0]

[0] https://news.ycombinator.com/newsfaq.html

Re: Ask HN: What have you created that deserves a second chance on HN?

#50

Post by patchorang »

I made a drum machine that I think is pretty cool - https://main.d28ilu31tegyi1.amplifyapp.com/ I taught myself how to program 15+ years ago because I wanted to make music software. Fast forward 15 years, and I've spent my whole career as a designer for B2B Saas. I wanted to re-learn some development stuff and going back to my original inspiration seemed like a good idea. (Still a bit in progress and sorry doesn't work on mobile, there is some Web Audio stuff I haven't figure out for mobile yet)

I also built a small app to learn my piano chords. You can play along with a MIDI keyboard. https://www.learnyourchords.com/

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