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Antidepressants help bacteria resist antibiotics: study

nature.com

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Re: Antidepressants help bacteria resist antibiotics: study

#61

Post by jklinger410 »

idontpost wrote: post #21
jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

> Being anti conspiracy and overly trusting of certain (cough cough) fields of science denotes an inability to rationalize. That's some word salad right there.

Fair criticism, not my cleanest rep. Will do better

Re: Antidepressants help bacteria resist antibiotics: study

#62

Post by [deleted] »

jklinger410 wrote: post #55
airstrike wrote: post #47

Earlier quoted context omitted.

> It's the role of science and government to find out which anti-biotics, which hormones, and which pesticides case increased rates of which cancers. Not if you subscribe to the precautionary principle https://en.wikipedia.org/wiki/Precautionary_principle "The principle is often used by policy makers in situations where there is the possibility of harm from making a certain decision (e.g. taking a particular course o…

But imagine how much revenue we'd be missing out on if every new invention that could shave a few cents off the bottom line had to be researched first? Just one of many brilliant decisions that the primarily white men who have ran this country throughout history made on behalf of all of us. Without our consent, of course. Good luck proving your dad's colon cancer was caused by industrial solvents in our water supply.…

[deleted]

Re: Antidepressants help bacteria resist antibiotics: study

#64

Post by unity1001 »

jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

Indeed. Its amazing how people can still rationalize the existing situation and help defend corporate sociopathy after all the corporate scandals that were revealed over the last few decades in which the corporations did not stop short of outright murder for profit. Avandia drug scandal comes to mind...

Re: Antidepressants help bacteria resist antibiotics: study

#65

Post by John23832 »

DonaldFisk wrote: post #60
John23832 wrote: post #37

Earlier quoted context omitted.

Phages are not the silver bullet that people think they are. First they're difficult to make and store (antibiotics are mostly shelf stable... phages aren't). Second, they are not broad spectrum. Third, (at least in the US) phage therapy hasn't taken off because the initial forays into phages showed that they can cause reactions. Lastly, not all bacteria have phage counterparts. So if you even could use phages, you'r…

They're highly specific, and are harder to administer. They're usually stored in glass phials which need to be kept in a refrigerator. Stomach acid needs to be neutralized if they're taken orally. If administered by injection, the strain used can only be used once as the body develops antibodies to it. Most of the scientific literature on them is in either Georgian or (if you're lucky) Russian. They're not without th…

I'm not saying that they can't be used. They can. People often take new(ish) tech as a cure-all.

There are still challenges though.

For bacteria with high resistance (which is what we have the biggest issue with), we've typically done a workup of the bacterium to target. In the worst case, these are what land people in the hospital. Hospital settings would be the best administration point for these therapies. The problem would still be the creation of the specific phages in a reasonable fashion. This would only really be available at major hospitals in major cities. And so... limited in usage.

I could see major hospitals keeping a large amount of gonococcal phages on hand though.

Edit::

One more thing. As far as antibiotic allergies (you mentioned beta lactams) we typically have antibiotic alternatives. Doxycycline is pretty much well tolerated by everyone. And it's available in pill form.

Re: Antidepressants help bacteria resist antibiotics: study

#68

Post by DonaldFisk »

bratwurst3000 wrote: post #45
John23832 wrote: post #37

Earlier quoted context omitted.

Phages are not the silver bullet that people think they are. First they're difficult to make and store (antibiotics are mostly shelf stable... phages aren't). Second, they are not broad spectrum. Third, (at least in the US) phage therapy hasn't taken off because the initial forays into phages showed that they can cause reactions. Lastly, not all bacteria have phage counterparts. So if you even could use phages, you'r…

Isnt it that phages can be engeneered to a specific bacteria? Also the other way around. The can be programmed with the dna of the bacteria. So pcr the bacteria then make phages that atack them. My knowledge is bad . Could you elaborate where the engeneering problem is and the cost factors? Thanks

They're numerous and widespread, so it should be possible to find the phage you want. If bacteria evolve to develop resistance to it, bacteriophage can evolve to overcome that resistance.

Re: Antidepressants help bacteria resist antibiotics: study

#69

Post by [deleted] »

stackbutterflow wrote: post #12
tokai wrote: post #4

Interesting and potentially dangerous. But as long as many millions of pigs are covered in antibiotic foam (which is just rinsed off into the drain), I'm not gonna lie sleepless over this. Resistant bacteria will cause humanity huge troubles if we don't manage to do something radical soon.

The answer is phages. But last time I went into the rabbit hole the TLDR was that it is not patentable so there's no money in it. And everyone needs a different phages cocktail. I sleep at night knowing that push come to shove someone will step in and mass produce machines to create personal phage cocktails.

[deleted]

Re: Antidepressants help bacteria resist antibiotics: study

#70

Post by throwanem »

jklinger410 wrote: post #52
frereubu wrote: post #23

Earlier quoted context omitted.

That's exactly what I took from "(cough cough) disorders".

Cough cough was not a respiratory reference. I simply am not going to stir up the pot by directly mentioning the fields that are corrupt or the specific disorders.

Why should anyone take you seriously when you openly admit lacking the courage of your convictions?
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