Antidepressants help bacteria resist antibiotics: study
1–10 of 139 posts
Re: Antidepressants help bacteria resist antibiotics: study
#2This seems a really week connection.
> In bacteria grown in well-oxygenated laboratory conditions, the antidepressants caused the cells to generate reactive oxygen species: toxic molecules that activated the microbe’s defence mechanisms. Most prominently, this activated the bacteria’s efflux pump systems, a general expulsion system that many bacteria use to eliminate various molecules, including antibiotics. This probably explains how the bacteria could withstand the antibiotics without having specific resistance genes.
So the study was:
* Done in a petri dish
* Done in an environment dissimilar to the human body
* Showed an adaptation to the environment unrelated to antibiotic resistance
Showing adaptation "efflux pumps" for oxygen removal and claiming it's applicable to antibiotics seems like claiming yoga mats are made from jet fuel because they both contain water.
It would be really interesting if they tested a null here which I don't see noted anywhere. If the adaptation happened in the oxygen rich environment without the antibiotic it would indicate that antibiotics are not causal.
Re: Antidepressants help bacteria resist antibiotics: study
#3Probably helps the bugs deal with their existential dread of trying to do battle inside of a body doped to kill them.
Re: Antidepressants help bacteria resist antibiotics: study
#4Interesting and potentially dangerous. But as long as many millions of pigs are covered in antibiotic foam (which is just rinsed off into the drain), I'm not gonna lie sleepless over this. Resistant bacteria will cause humanity huge troubles if we don't manage to do something radical soon.
Re: Antidepressants help bacteria resist antibiotics: study
#5Fascinating, the idea is that by inducing a stress response bacteria are virilized in a sense.
It's interesting they picked antidepressants to do so but the logic should apply to many substances people like to kill bugs
Like green tea and spices which hinder bacteria should also make them resistant to antibiotics.
Re: Antidepressants help bacteria resist antibiotics: study
#6This seems a really week connection. > In bacteria grown in well-oxygenated laboratory conditions, the antidepressants caused the cells to generate reactive oxygen species: toxic molecules that activated the microbe’s defence mechanisms. Most prominently, this activated the bacteria’s efflux pump systems, a general expulsion system that many bacteria use to eliminate various molecules, including antibiotics. This pro…
It seems the mechanism is general enough that green tea, spices that are lauded for harming bacteria might be making them more virulent
Re: Antidepressants help bacteria resist antibiotics: study
#7I wonder if antidepressants protect your gut microbiome and the SSRI aspect is over stated. Would be very hard to disambiguate those two effects I suspect.
Re: Antidepressants help bacteria resist antibiotics: study
#8This seems a really week connection. > In bacteria grown in well-oxygenated laboratory conditions, the antidepressants caused the cells to generate reactive oxygen species: toxic molecules that activated the microbe’s defence mechanisms. Most prominently, this activated the bacteria’s efflux pump systems, a general expulsion system that many bacteria use to eliminate various molecules, including antibiotics. This pro…
This article mentions that a study was done in humans and found no effect. https://english.elpais.com/science-tech/2023-01-24/study-sug...
Re: Antidepressants help bacteria resist antibiotics: study
#9Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming.
Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food.
Being anti conspiracy and overly trusting of certain (cough cough) fields of science denotes an inability to rationalize.
Re: Antidepressants help bacteria resist antibiotics: study
#10Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…
That last sentence is often used to criticize economics but haven’t heard it on harder “sciences” before.