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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#971

Earlier quoted context omitted.

> It’s so hard to eat healthy, I honestly cannot fathom how people do it. Learn to cook well so that eating out would result in lower quality meals compared to what you could make yourself. Once you're controlling what goes into your meals, instead of outsourcing it, that makes it easier to control portion sizes, how much fat/oils go into things (I've found that restaurant dishes have an absurd amount of fat in them…

“Has a high amount of fat” isn’t the same thing as “unhealthy”. “Has a high amount of calories” isn’t either. Wanting to lose weight isn’t necessarily about health, and eating a lot of fat is an effective way to lose weight.

Eating a lot of fat is an effective way to lose weight, I agree.

However the fats used in restaurants are often used for frying, and likely have been used repeatedly for many hours. Oils used for frying can quickly produce compounds that are not great to consume, like various aldehydes, VOCs, free radicals etc[1]. If they've been used for hours, the chances of those compounds being in your food are high.

They are often low quality, as well, like soybean oils that can be high in fats that can be unhealthy in excess and might contribute to CVD.

I bring up the fat thing not because I think fats are the reason why people gain weight, I'm well aware of how high fat low carb diets are effective. I bring it up because restaurants often put fats into food you might not put it in at home, and the food can soak a lot of it up, turning what might be a 500 calorie dish into something that's 1200 calories or more. If you're trying to watch what you eat, eating out can make that hard because you don't know exactly how much food you're actually eating, and you can't really rely on nutritional breakdowns you might find online or from the establishments themselves.

The foods the fats are in also seem to be high in carbohydrates, which isn't great for ketosis.

I also bring it up because of Ulillillia's decision to degrease the pizzas that were the only thing he ate. By doing that he was able to lose weight while literally only eating pizza for every meal for years.

[1] https://news.ycombinator.com/item?id=32818910

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#972

Earlier quoted context omitted.

> It’s so hard to eat healthy, I honestly cannot fathom how people do it. Learn to cook well so that eating out would result in lower quality meals compared to what you could make yourself. Once you're controlling what goes into your meals, instead of outsourcing it, that makes it easier to control portion sizes, how much fat/oils go into things (I've found that restaurant dishes have an absurd amount of fat in them…

There's a lot of words here so you took some time to write this. Who is it for? Why do you think this is a new/novel idea the person you are replying to, and others reading it, has/have not heard before?

I am sorry that my post bothered you, I will keep your sensibilities in mind the next time I choose to share personal experiences on HN.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#973

Earlier quoted context omitted.

Why? Plenty of young and healthy people died of COVID. Only some vaccines are mRNA types, and, in the USA anyway, all vaccines went through the same testing process as any other medication, they simply sped the process up by layering some of the steps - all that means is that rather than wait to see if one study passes before doing the next one (save money or whatever), they just overlapped them. Even for MRNA vaccin…

> Plenty of young and healthy people died of COVID. The median age of death due to COVID-19 in the UK[1], as of January 2021, was 83. I haven't checked but there is little reason to think this has changed much. From page 9 of Public Health England's Excess Weight and COVID-19 report[2] of July 2020: > patients with COVID-19 living with overweight (BMI ≥25kg/m2) or obesity (BMI ≥30kg/m2), compared with patients with a…

Correct, more unhealthy and old people died of COVID.

More drunk people are involved in car accidents than sober. Yet I still put on my seatbelt.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#974

Earlier quoted context omitted.

Why? Plenty of young and healthy people died of COVID. Only some vaccines are mRNA types, and, in the USA anyway, all vaccines went through the same testing process as any other medication, they simply sped the process up by layering some of the steps - all that means is that rather than wait to see if one study passes before doing the next one (save money or whatever), they just overlapped them. Even for MRNA vaccin…

I'm with you except for the cold vaccines line. Did you mean flu vaccines?

yes, thank you

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#975

Earlier quoted context omitted.

Being a young and very healthy person I felt this way about the COVID vaccine.

Why? Plenty of young and healthy people died of COVID. Only some vaccines are mRNA types, and, in the USA anyway, all vaccines went through the same testing process as any other medication, they simply sped the process up by layering some of the steps - all that means is that rather than wait to see if one study passes before doing the next one (save money or whatever), they just overlapped them. Even for MRNA vaccin…

Not worried about flu vaccines because they’ve been around forever. MRNA vaccines are relatively new and weren’t observed for long term side effects like other vaccines.

Johns Hopkins to me is part of the same machine making anyone who doesn’t get a vaccine an outcast. I would trust them about as much as the CCP regarding COVID’s origins.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#977

Earlier quoted context omitted.

> have got average people to think it's perfectly normal to try putting random chemical compositions into their bodies and see what happens This smells like you devoured some anti-vaxxer BS, btw. But for the record, these things go through a ton of testing and clinical trials. The reason science types are excited is BECAUSE this class of drug looks safe AND effective... based on the data. (And I'm also down 35+ lbs o…

if expressing any less-than-positive opinions about pharmaceutical corporations is enough for you to make an immediate learned mental association with a popular dismissive political buzzword label, then I suggest asking yourself why exactly this is the first thing that came to mind, and what that might mean from a marketing perspective. I was prescribed 20mg daily of time-release amphetamines when I was 13, and that…

That's fair, but speaking as an occasional 15mg Adderall XR person for about 10 years now- You're not addicted to it. The downer when you go off it will take a few days (I take 2 days, you may take a day or 2 more) and will be a bitch, but it will pass. I go off mine on weekends so that I don't adapt to it.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#978

Earlier quoted context omitted.

Why? Plenty of young and healthy people died of COVID. Only some vaccines are mRNA types, and, in the USA anyway, all vaccines went through the same testing process as any other medication, they simply sped the process up by layering some of the steps - all that means is that rather than wait to see if one study passes before doing the next one (save money or whatever), they just overlapped them. Even for MRNA vaccin…

Not worried about flu vaccines because they’ve been around forever. MRNA vaccines are relatively new and weren’t observed for long term side effects like other vaccines. Johns Hopkins to me is part of the same machine making anyone who doesn’t get a vaccine an outcast. I would trust them about as much as the CCP regarding COVID’s origins.

This is absolute disinformation and you should be ashamed. Delete this.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#979

Earlier quoted context omitted.

The next gen lily drug is expected to cost $1500 for a 30-day supply. The US government stated $18000 per year was a fair price to pay. There is no money in the cure. We sell you the disease, and charge you 5x for the treatment. Fwiw I am obese.

But insurance covers most of it?

[deleted]

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#980

Earlier quoted context omitted.

While we are drowning in quick to consume, non-nutritious, calories, we also have higher levels of anxiety, stress and more distractions. To your comment, maybe more countries should attempt to implement programs similar to the UK's success in lowering sodium intake by slowly adjusting the sodium content of all manufacturered foods. https://www.nature.com/articles/jhh2013105

> we also have higher levels of anxiety, stress Why should that be true? Your kids aren't going off to WW2 to die. You aren't going to starve if bugs ate your crops. You aren't going to get clubbed and robbed if you follow a forest path.

By that logic, the phenomenon of professional burnout thanks to constant stress shouldn't be a thing in IT, and yet it clearly is.
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