771–780 of 1001 posts
Earlier quoted context omitted.
> one of the foremost experts of fat metabolism Is it correct that the source is a veterinary anaesthesiolgist? https://news.ycombinator.com/item?id=34252195
Yes, he is the world's leading expert on this subject because credentials aren't everything
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
This line alone tells me you're legit be a use nobody talks about this aspect of doing what needs to be done to lose that kind of weight.
From everything I've heard, I'd take this class of drug in a heartbeat if I thought I had any chance at all of getting a prescription. It is apparently a double edged sword that all of my health metrics peg me at above average health, except that I'm a bit overweight again after the COVID times.
Earlier quoted context omitted.
I'm also on one of these drugs (Tirzepatide) and have been for a few months. The first time I remember knowing I was fat was when a babysitter made fun of me for it at age 6. I've been fat ever since and I'm in my late 30s now. I've lost significant amounts of weight (60+ pounds) three times in my adult life, through simple calorie restriction (intermittent fasting, including before I'd ever heard the term). Every ti…
Please try eating only liver, eggs, and ribeye steaks and drinking only water. You can absolutely stuff yourself on this diet and you will nevertheless get in shape. It breaks my heart that people have such an upside down idea about what healthy food is -- people think they should avoid red meat and eat fruits and vegetables and "heart healthy grains" when in fact the only thing they should eat is red meat. It is a t…
Worse, it’s excruciatingly boring. The 60th serving of fatty steak is no longer delicious. I lusted for a crouton. Even onions are a cheat in a glycemic load regime.
When I was single, strategies like having no sugar, alcohol, or refined carbs in the house were practical, but living with a family and especially with young kids, they really aren’t.
I regained it all and more. I’ve made follow-on efforts and had several +/- 30lb swings.
I started tirzepatide three months ago. I echo what others have said above: I never understood satiety before this. Keeping keto takes excruciating willpower in comparison. I now know what it feels like to eat 3/4 of a normal dinner with balanced macros and not think about food till lunchtime the next day.
There’s a big difference between maintaining constant vigilance against desire and having none.
Earlier quoted context omitted.
The body is an energy equation to be balanced. Physics defines that. What you are talking about substantially in your post is about willpower with regards to eating and exercise which is totally different.
I am very much not talking about willpower. I am saying it is NOT about willpower. And sure, there is an energy equation here thermodynamically, but it is unhelpful. It would be something like: Calories in * X = Calories consumed * Y + Fat stored * Z Where X, Y and Z are unknown and barely controllable factors related to hunger, type of food, digestion, microbiome, hormones, genetics, metabolism, environment, society…
Earlier quoted context omitted.
Fat guy here: these side effects are pretty scary for somebody like me. 3 months of noticeably extra fatigue on top of my current baseline level of exhaustion seems to threaten serious psychological effects. 3 months of brain-fog sounds like a great way to get fired and really fuck up my life. If my "gastro situation" was noticeably worse than the unpredictable wildy-swinging nightmare it already is, I honestly have…
[flagged]
Earlier quoted context omitted.
Fat guy here: these side effects are pretty scary for somebody like me. 3 months of noticeably extra fatigue on top of my current baseline level of exhaustion seems to threaten serious psychological effects. 3 months of brain-fog sounds like a great way to get fired and really fuck up my life. If my "gastro situation" was noticeably worse than the unpredictable wildy-swinging nightmare it already is, I honestly have…
[flagged]
Earlier quoted context omitted.
Disagree. People genuinely enjoy those foods, because they're tasty and flavorful. And there's zero reason to believe that they're substantially unhealthy unless consumed to the point of sustained caloric surplus. We know this because we have hunter-gatherer populations who consume 50% of their diets in sugar (e.g. the Hadza) or fats (e.g. Intuit), and they have none of the diseases of abundance found in modern popul…
I think the only way you can make this argument is to have a completely value agnostic perspective and believe that any individual value curve is good. Is Meth good because people clearly value it enough to destroy their lives to get more? No. It isn't - we know individual value assessment isn't always right. People genuinely enjoy those foods because they're closer to their bliss point than natural analogues. Increa…
Interestingly, a reduction in consumption of processed foods would also likely have a significant impact on the need for health interventions with drugs. We have massive industries propped up by people’s cravings for junk.
Earlier quoted context omitted.
> The thing is, I'm never full. I can eat until I physically can't eat anymore (not something I do regularly, of course), and as soon as my stomach has emptied a bit, I feel fairly hungry again. "Eat until you feel full" is literally a human experience I had never really had. I feel exactly the way you do, and yes, I was fat, lost it in one go and never gained it back. I try to keep my BMI around 18, never went over…
> Not that hard to stop yourself from going to the store again or ordering more Well, actually... I'm fat. Like BMI 40 fat. Most of my life I have been fat. I was laughed at in school for it, as far back as I can remember. It probably wasn't all that bad when I think back. Certainly not as bad as now. But I was the fat kid in class, and I felt like the fat kid. Anyway, I have lost a lot of it at a few points. Once by…
In the movie he does some of the things you mention, but I don't think he was vilified in the movie. I saw him as a hero at the end. Some fat people on youtube were very offended by "The Whale", I'm curious if it is universally offensive to large people.
This is good news (probably?), but wanted to chime in with a tangent. Also going to preface this by saying I have struggled with weight my entire life and have lost and gained substantial weight through diet alone, always gaining it back and then some — but I think I found something that has worked for me and I have been reflecting on what I wish I was told a long time ago. It's not necessarily a problem to be "obese…
What does your plan look like long-term? Are you just going to keep gaining muscle and working out for the rest of your life, or do you plan to stop?
Obviously your TDEE is going to go up with more muscle. I wonder if there's a stable point where you can eat a 'normal' (read: not protein heavy) diet while working out, so that muscle is only maintained.
If I knew it was safe in the long term I’d take it in a heartbeat. However, I’m concerned that there could be long term issues with the drug (perhaps a resistance/“yo-yo” effect where the potency wears off and I gain back my original weight plus more than I would have otherwise over, say, 10 or 20 years).
Is that the sort of thing that’s in the realm of the possible/plausible or is this more like a vaccine where there are some strong theoretical reasons why we don’t expect it to have long term issues?