‘Breakthrough’ obesity drugs that have stunned researchers • Hacker News Board

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#751

Post by Gwarzo » Thu, Jan 05, 2023, 4:00 AM UTC

danielvaughn wrote: post #641

windpower wrote: post #526

Earlier quoted context omitted.

I'm also on one of these drugs (Tirzepatide) and have been for a few months. The first time I remember knowing I was fat was when a babysitter made fun of me for it at age 6. I've been fat ever since and I'm in my late 30s now. I've lost significant amounts of weight (60+ pounds) three times in my adult life, through simple calorie restriction (intermittent fasting, including before I'd ever heard the term). Every ti…

I was just saying the exact same thing to my wife yesterday. We’re both trying to lose weight, for the millionth time in the 20 years we’ve been together. Exasperated, I just said “I don’t get it. I was an artist who had no technical background, and was able to teach myself computer science and now I’m a highly successful engineer. I did that. And yet I can’t lose 10 pounds to save my life.” It’s so hard to eat healt…

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#752

Post by jononomo » Thu, Jan 05, 2023, 4:01 AM UTC

Sophistifunk wrote: post #690

0xB31B1B wrote: post #21

I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…

Fat guy here: these side effects are pretty scary for somebody like me. 3 months of noticeably extra fatigue on top of my current baseline level of exhaustion seems to threaten serious psychological effects. 3 months of brain-fog sounds like a great way to get fired and really fuck up my life. If my "gastro situation" was noticeably worse than the unpredictable wildy-swinging nightmare it already is, I honestly have…

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#753

Post by not_kurt_godel » Thu, Jan 05, 2023, 4:02 AM UTC

rubicon33 wrote: post #653

scarmig wrote: post #649

Earlier quoted context omitted.

> It’s so hard to eat healthy, I honestly cannot fathom how people do it. When I started taking semaglutide, I finally understood it. I'd eat a salad... and be full and more than satisfied! I'd look at a muffin right after lunch, and go "eh, better things to do with my time" instead of immediately having an overriding desire to eat eat eat. Before, I could eat half a pizza and still be hungry (way out of what my body…

> Too many people are convinced that everyone has the same subjective experiences of hunger and craving, but it's simply not the case. Some people implicitly hold this idea because it's a convenient ideology that allows people to morally congratulate themselves for having a functioning satiety circuit. Where does this line of thinking stop? Is everything pre-determined by genetics? Is everyone who is smarter than me,…

Why are you more worried about "good old fashioned hard work and discipline" than taking a scientific and results-oriented approach to improve people's lives? Do you want to see people toil and suffer for its own sake?

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#754

Post by Gwarzo » Thu, Jan 05, 2023, 4:03 AM UTC

throwawayfatty wrote: post #722

auganov wrote: post #643

Earlier quoted context omitted.

> The thing is, I'm never full. I can eat until I physically can't eat anymore (not something I do regularly, of course), and as soon as my stomach has emptied a bit, I feel fairly hungry again. "Eat until you feel full" is literally a human experience I had never really had. I feel exactly the way you do, and yes, I was fat, lost it in one go and never gained it back. I try to keep my BMI around 18, never went over…

> Not that hard to stop yourself from going to the store again or ordering more Well, actually... I'm fat. Like BMI 40 fat. Most of my life I have been fat. I was laughed at in school for it, as far back as I can remember. It probably wasn't all that bad when I think back. Certainly not as bad as now. But I was the fat kid in class, and I felt like the fat kid. Anyway, I have lost a lot of it at a few points. Once by…

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#755

Post by balls187 » Thu, Jan 05, 2023, 4:04 AM UTC

cactusplant7374 wrote: post #602

balls187 wrote: post #590

Earlier quoted context omitted.

The next gen lily drug is expected to cost $1500 for a 30-day supply. The US government stated $18000 per year was a fair price to pay. There is no money in the cure. We sell you the disease, and charge you 5x for the treatment. Fwiw I am obese.

But insurance covers most of it?

No. Not at all.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#756

Post by jononomo » Thu, Jan 05, 2023, 4:04 AM UTC

MajimasEyepatch wrote: post #333

halfmatthalfcat wrote: post #291

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This is a ridiculous comment. Statistically, there is no weight loss strategy that has been found to work long term at the population level except for bariatric surgery (and now, apparently, these drugs, but we'll see how things look in a few years). Sure, one individual person can pull it off with enough willpower and support and luck. But at a population level, we know definitively that "grind it out with exercise,…

The carnivore diet (eat only liver, eggs, and ribeye steaks, and drink only water) would work to cure obesity at a population level. It would also end chronic disease in society.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#757

Post by jononomo » Thu, Jan 05, 2023, 4:06 AM UTC

JamesBarney wrote: post #548

smooth_remmy wrote: post #275

Petro Dobromylskyj is one of the foremost experts of fat metabolism. He has a blog called Hyperlipid where he's been blogging about fat metabolism and interpreting research for close to 10 years. He thinks the GLP-1 inhibitor drugs will be a disaster in the long term because they 1) cause weight loss but also 2) cause the body to create lots of new adipocyte (fat cells). Increasing the number of adipocytes is very un…

I don't know if I'd call a veterinary anaesthetist a foremost expert on fat metabolism. His thoughts on insulin signaling are not consistent with the consensus among obesity researchers. He thinks glp-1 works through uncoupling or fat browning which is just not true. The consensus among most obesity researchers is the cause of obesity is primarily neurological, not metabolic. Basically the brain can't properly regula…

He is basically the world's leading expert, but you can only see credentials, lol.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#758

Post by ip26 » Thu, Jan 05, 2023, 4:06 AM UTC

drowsspa wrote: post #128

dmix wrote: post #58

Earlier quoted context omitted.

> I don't want to eat empty carbs, anywhere near as much. Because I feel like they make me feel sick. I did a keto diet obsessively for a while and I still have a psychological revulsion to drinking coke or eating cake even a year later. Those sorts of things are long term wins.

I wish I got to this stage where people lose their cravings. While I'm at home I can control my diet pretty well, but as soon as there's junk food in front of me I look like a pig. And I've lost like 30 pounds, to put it into perspective.

I don't think the cravings go away exactly; you just layer a mild (defensive?) eating disorder on top. For example, when I eat valueless empty carbs, the waves of depression & the feeling of dread in the pit of my stomach prevent me from even tasting it or enjoying it. Winning...?

It's a strange, thin line to walk. Trans fats are unhealthy in any quantity, so I refuse to eat them. But they are still (secretly) all over the place, so in practice it looks a lot like an eating disorder.

It's easy to take it too far, but "just because you're paranoid, does not mean they're not out to get you."

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#759

Post by jononomo » Thu, Jan 05, 2023, 4:07 AM UTC

wolverine876 wrote: post #423

smooth_remmy wrote: post #275

Petro Dobromylskyj is one of the foremost experts of fat metabolism. He has a blog called Hyperlipid where he's been blogging about fat metabolism and interpreting research for close to 10 years. He thinks the GLP-1 inhibitor drugs will be a disaster in the long term because they 1) cause weight loss but also 2) cause the body to create lots of new adipocyte (fat cells). Increasing the number of adipocytes is very un…

> one of the foremost experts of fat metabolism Is it correct that the source is a veterinary anaesthesiolgist? https://news.ycombinator.com/item?id=34252195

Yes, he is the world's leading expert on this subject because credentials aren't everything

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#760

Post by Gwarzo » Thu, Jan 05, 2023, 4:07 AM UTC

rubicon33 wrote: post #653

scarmig wrote: post #649

Earlier quoted context omitted.

> It’s so hard to eat healthy, I honestly cannot fathom how people do it. When I started taking semaglutide, I finally understood it. I'd eat a salad... and be full and more than satisfied! I'd look at a muffin right after lunch, and go "eh, better things to do with my time" instead of immediately having an overriding desire to eat eat eat. Before, I could eat half a pizza and still be hungry (way out of what my body…

> Too many people are convinced that everyone has the same subjective experiences of hunger and craving, but it's simply not the case. Some people implicitly hold this idea because it's a convenient ideology that allows people to morally congratulate themselves for having a functioning satiety circuit. Where does this line of thinking stop? Is everything pre-determined by genetics? Is everyone who is smarter than me,…

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