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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#711

Post by anigbrowl »

Firmwarrior wrote: post #617
anigbrowl wrote: post #427

Earlier quoted context omitted.

I had the same reaction. I minimize oxidative stress on my body by being selective about what I eat: having a bit less of some delicious things and eating a bit more of some boring foods that I know are good for me. Also, fuck 'longevity.' The population of the world has doubled during my lifetime and this is a Bad Thing which is wiping out vast numbers of other species. Call me misanthropic if you like but humans ar…

Man, I'm really sick of this outlook. There's a whole solar system here full of unlimited space and resources. A hundred years from now, if someone feels like it they'll be able to live in an O'Neill cylinder the size of San Francisco by themselves, and it won't be any weirder than /r/vandwellers today

You've changed my mind. I now plan to live to at least 150 so I can be around to say 'I told you so' in 2123.

Seriously, 30-40 years ago I would have eagerly agreed with you. Much as I continue to like technology and feel optimistic about it overall, I greatly doubt that a century from now there will be any non-military space colonies in existence; long term existence is more likely to exist in silico than for biological bodies. One major influence on my thinking about this is the fact that we landed people on the Moon from 1969 to 1972 and then just gave up on it for 50 years. Now in middle age, I cannot overstate my sense of betrayal by earlier generations that decided to devote themselves to financial engineering instead.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#712

Post by xvilka »

ashwagary wrote: post #652
windpower wrote: post #526

Earlier quoted context omitted.

I'm also on one of these drugs (Tirzepatide) and have been for a few months. The first time I remember knowing I was fat was when a babysitter made fun of me for it at age 6. I've been fat ever since and I'm in my late 30s now. I've lost significant amounts of weight (60+ pounds) three times in my adult life, through simple calorie restriction (intermittent fasting, including before I'd ever heard the term). Every ti…

>I've heard people say that the solution is to eat (healthy food) when you're hungry, and stop when you're full. The thing is, I'm never full. I can eat until I physically can't eat anymore (not something I do regularly, of course), and as soon as my stomach has emptied a bit, I feel fairly hungry again. "Eat until you feel full" is literally a human experience I had never really had. I hear people following a carniv…

> high protien, high fat, and zero carb

Basically a keto diet, of course it works due to ketosis.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#713

Post by icambron »

altcognito wrote: post #586
windpower wrote: post #526

Earlier quoted context omitted.

I'm also on one of these drugs (Tirzepatide) and have been for a few months. The first time I remember knowing I was fat was when a babysitter made fun of me for it at age 6. I've been fat ever since and I'm in my late 30s now. I've lost significant amounts of weight (60+ pounds) three times in my adult life, through simple calorie restriction (intermittent fasting, including before I'd ever heard the term). Every ti…

I have gerd, and was like, I was wondering if this would make it easier for me to eat small amounts and not have as much heartburn... then I read this: > As for side effects: I've had some heartburn, but none of the other commonly reported side effects. And I looked up the less side effects, it is a laundry list of gerd symptoms. I can confirm, these symptoms will help you lose weight, but I mean that tounge in cheek…

One of the likely factors in my gerd issues is being about 20 lbs overweight, so I wonder how this balances out.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#715

Post by le-mark »

etothepii wrote: post #699
heavyset_go wrote: post #669

Earlier quoted context omitted.

> It’s so hard to eat healthy, I honestly cannot fathom how people do it. Learn to cook well so that eating out would result in lower quality meals compared to what you could make yourself. Once you're controlling what goes into your meals, instead of outsourcing it, that makes it easier to control portion sizes, how much fat/oils go into things (I've found that restaurant dishes have an absurd amount of fat in them…

There's a lot of words here so you took some time to write this. Who is it for? Why do you think this is a new/novel idea the person you are replying to, and others reading it, has/have not heard before?

Indeed!

> Sometimes I crave pancakes, despite them being nearly 100% carbohydrates. I eventually ended up with a recipe that substitutes wheat flour with almond and coconut flour, and to replace the syrup, a berry sauce reduction sweetened with erythritol. Barely any carbohydrates and the berry sauce is better than maple syrup,

This reads like an elaborate troll, at that!

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#716

Post by argella »

bioemerl wrote: post #411
MajimasEyepatch wrote: post #369

Earlier quoted context omitted.

The term "natural weight" as used here is misleading. It does not mean that people are supposed to be a particular weight. It refers to the idea that something—whether it's diet, genetics, environmental factors, or something else—influences the body's weight regulation mechanisms to "prefer" a certain body weight, and changing that is very, very hard. Think of it like body temperature: normally, your body maintains a…

If this were true I would not expect that changes in our lifestyle would cause broad scale weight increases like they have. I'm very skeptical humans are built with an average set weight way up in the unhealthy range. Or maybe this is the case, but it is thrown off hard by our modern diets. Our natural set point is in the healthy range, but our meal is x calories per Y food now so it ends up artificially high. The ex…

"The term "natural weight" as used here is misleading."

It just means that bodies have a set point that they'll defend. And that weight changes. If you get fat, no matter how you do it, your body will defend that weight and if you lose will take action, increase hunger, reduce metabolism, etc. making it near impossible to keep it off even if you lose it.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#717

Post by ABCLAW »

dcolkitt wrote: post #152
rajin444 wrote: post #56

This drug is a net good for society, but we have to fix the root problem. Much of the food we eat is filled with addictive ingredients (sugar, excess fats/oils, etc) that provide little nutritional value but are highly addictive. We’re subsidizing companies that create unhealthy addictive food and subsidizing companies to create drugs to counter the unhealthy addictive food. This is an enormous waste of resources.

Disagree. People genuinely enjoy those foods, because they're tasty and flavorful. And there's zero reason to believe that they're substantially unhealthy unless consumed to the point of sustained caloric surplus. We know this because we have hunter-gatherer populations who consume 50% of their diets in sugar (e.g. the Hadza) or fats (e.g. Intuit), and they have none of the diseases of abundance found in modern popul…

I think the only way you can make this argument is to have a completely value agnostic perspective and believe that any individual value curve is good. Is Meth good because people clearly value it enough to destroy their lives to get more? No. It isn't - we know individual value assessment isn't always right.

People genuinely enjoy those foods because they're closer to their bliss point than natural analogues. Increasing salt, fat and sugar content of processed foods doesn't mean they're better for consumers. They just mean they're more addictive. People consume more of them and are more likely to purchase them in the future.

https://en.wikipedia.org/wiki/Bliss_point_(food)

We have no issues identifying that restrictions on tobacco are acceptable from a public health standpoint - the same chemical reward hijacking is being done with food.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#718

Post by fortran77 »

auganov wrote: post #643
windpower wrote: post #526

Earlier quoted context omitted.

I'm also on one of these drugs (Tirzepatide) and have been for a few months. The first time I remember knowing I was fat was when a babysitter made fun of me for it at age 6. I've been fat ever since and I'm in my late 30s now. I've lost significant amounts of weight (60+ pounds) three times in my adult life, through simple calorie restriction (intermittent fasting, including before I'd ever heard the term). Every ti…

> The thing is, I'm never full. I can eat until I physically can't eat anymore (not something I do regularly, of course), and as soon as my stomach has emptied a bit, I feel fairly hungry again. "Eat until you feel full" is literally a human experience I had never really had. I feel exactly the way you do, and yes, I was fat, lost it in one go and never gained it back. I try to keep my BMI around 18, never went over…

[flagged]

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#719

Post by fortran77 »

tyleo wrote: post #479
0xB31B1B wrote: post #21

I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…

> Losing weight was extremely challenging and socially isolating. How was it socially isolating? I’m curious because I exercise and diet and this is not my experience. I understand it being challenging though.

[flagged]

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#720

Post by joe_the_user »

8note wrote: post #246
joe_the_user wrote: post #187

Earlier quoted context omitted.

I don't think it's half-plausible to compare Hadza or Intuit diets to a Big Mac and a soda. Neither transfats nor processed sugars are in the Hadza diet, just for example.

Isn't honey a processed sugar? The processing being done by a bee instead of a machine

By this "reasoning", all food is processed amino acids and related elements. But despite such sophistry, there's a measurable difference between a human-machine-processed diet and an animal-processed diet. Good figure.
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