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‘Breakthrough’ obesity drugs that have stunned researchers

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621–630 of 1001 posts

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#621

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OP commented on a weight-loss scheme of eating every other day. Given the social attitudes around eating (which I suspect to be the #1 most common social activity), this alone has the obvious potential to eliminate ~%50 of the most likely socializing opportunities.

You can plan your fasting days around it. If you have some crazy social schedule, maybe this doesn't work. But I don't go out every night.

Sounds convenient...

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#622
post #479

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> Losing weight was extremely challenging and socially isolating. How was it socially isolating? I’m curious because I exercise and diet and this is not my experience. I understand it being challenging though.

OP commented on a weight-loss scheme of eating every other day. Given the social attitudes around eating (which I suspect to be the #1 most common social activity), this alone has the obvious potential to eliminate ~%50 of the most likely socializing opportunities.

If you're not eating every other day you can still go to the eating place and sit with folks. Also you can just talk more since they have to eat and you don't. Sounds like MORE socializing.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#623
post #190

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And it makes more logical sense to you that everyone is just weak-willed?

s/weak-willed/addicted/ There. Fixed it for you :) Yes, to me it seems like capitalism creates a society where most people get addicted just trying to cope with everyday life. For some it's alcohol, for some it's OxyContin, for some it's food, for some it's all-nighters in World of Warcraft. "59.3 million (21.4%) people over age 12 used illicit drugs in the past year." "Underage [..] 29% reported drinking alcohol" ht…

And of course, the modern solution is to get them addicted to a new drug!

The top comment even recommends that everyone should be taking it. Yikes.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#624
post #479

Earlier quoted context omitted.

> Losing weight was extremely challenging and socially isolating. How was it socially isolating? I’m curious because I exercise and diet and this is not my experience. I understand it being challenging though.

Eating food and drinking alcohol is a core part of most social activities. When you're losing weight, you can't really fuck up, you really need to stick to your diet. I found it difficult to maintain my diet in social settings (going to a friends party, eating at a restaurant with friends, going to a bar to celebrate something, etc) so I just stopped doing all of those things for 8 months. Like, if you're trying to q…

That makes sense but it may also be that you just need to make different social circles. There are tons of casual sports teams, for example, and those people are all bonding over playing volleyball casually (not at a high level or something) or things like hiking. Now your social activities are helping you lose weight

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#625

This drug is a net good for society, but we have to fix the root problem. Much of the food we eat is filled with addictive ingredients (sugar, excess fats/oils, etc) that provide little nutritional value but are highly addictive. We’re subsidizing companies that create unhealthy addictive food and subsidizing companies to create drugs to counter the unhealthy addictive food. This is an enormous waste of resources.

> This is an enormous waste of resources

Of course it is, which is fantastic for the economy. Like the Industrial War Complex, it's horrifically bad for people and resources, but does wonders for the pockets of those in power

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#626

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I mean, if you have perfect bloodwork and a marvel movie body probably not necessary but otherwise yes. Heart disease, hypertension, high cholesterol, colon cancer rates are rising amongst everyone, even thin people. These drugs positively impact indicators of these things in everyone. Longevity makers have been betting on metformin for a long time and these drugs are like a supercharged metformin

A marvel movie body is made through injecting steorids.. not living healthily.

I truly wish more people were aware of this. The unrealistic expectations generated as a result of the silence around the topic is shameful.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#627

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If this were true I would not expect that changes in our lifestyle would cause broad scale weight increases like they have. I'm very skeptical humans are built with an average set weight way up in the unhealthy range. Or maybe this is the case, but it is thrown off hard by our modern diets. Our natural set point is in the healthy range, but our meal is x calories per Y food now so it ends up artificially high. The ex…

I think you're misunderstanding. There is no "natural set point." The set point moves up and down based on hormones, genes, diet, environment, medication, etc. And the very act of gaining weight causes your body's set point to move up, because of how weight gain affects your hormones. Unfortunately the set point is pretty sticky, and once it moves up, it does not like to move back down, in part because for most of an…

> And the very act of gaining weight causes your body's set point to move up, because of how weight gain affects your hormones. Unfortunately the set point is pretty sticky, and once it moves up, it does not like to move back down, in part because for most of animal history, weight loss is a sign of starvation.

Kind of, but increasing doesn't go indefinitely either. People have multiple "set points", not one moveable one, long known among people intentionally increasing their weight as "plateaus".

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#628
post #584

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What finally got me on right way on controlling hunger was just getting used to eating once a day and dropping a lot of the quick-burning foods that made me go hungry quicker. Not necessarily going super healthy but stuff like eating less bread/pasta and more say baked potatoes so still nice tasty food that doesn't get me into diet sadness mood, just shifting away from carbs Also figuring out when I'm "brain hungry"…

Yeah, I've never struggled with weight the way other comments in this thread have, but I made similar changes when I was younger and they've been one of the best things I've done. I have one largish meal a day, with one smaller or a snack, and focus on low GI foods but in a mild way. When I get that "brain is bored" style hunger I go for tea with a squirt of water enhancer in it lately.

Yeah when I tried the "eat a bunch of small meals during the day" way I felt like some constantly munching pasture animal and also had to plan for all that. And any social plans threw a wrench in it, as getting used to frequent meals also made me go brain hungry quicker.

Now getting some frozen pizza for dinner coz I'm lazy/don't have time no longer ruins diet pace for this week

> When I get that "brain is bored" style hunger I go for tea with a squirt of water enhancer in it lately.

Anything with a bunch of milk works well for me for quashing hunger. Weirdly enough I usually feel more hungry in the evening than morning next day (at the very least for first 1-2 hours)

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#629

> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.

I've heard this referred to as body "set points", and I've yet to see anything very convincing that set points are a thing. It doesn't really make sense that the body would "prefer" a body weight that is tremendously inefficient and contraindicated. More likely, in my opinion, what may be seen as a "set point" may be more akin to metabolic damage that simply takes time to heal once the pathology is actually being properly addressed.

Also, people simply can't be trusted when it comes to self-reporting of their own regimen. Whether it's not being honest with one's self, or being embarrassed, ill informed, or plain delusional, lots of people will report that they've done "all the right things" to lose weight when they in fact have not. It's far more common that people suffering from obesity remain fat because they are thwarting their own progress, or are being given shitty advice from crackpot dieticians, and less common that there is some chronic hormonal condition that can't be corrected by diet. If your pancreas is still working, as well as your thyroid, your pituitary, your hypothalamus, etc., you probably can correct your obesity without drugs.

But people want the "pill" or the "shot", even though the chances are really good that they could get most of the work done cutting out exogenous sugar and alcohol. And I can't necessarily blame them because I obesity drugs can be a life changing thing for those stuck in the 300+ lbs range. What worries me about these kind of drugs is if people think it's okay to get fat and prediabetic because they can just get a prescription. I guess that's great if they can, but that also seems like a form of low level megalomania of sorts, and results in one fewer thing for people to take personal responsibility over. It's good for the mind to put effort and work into something. It infantilizes the mind to allow it to not have to put rigor into anything.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#630

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The next gen lily drug is expected to cost $1500 for a 30-day supply. The US government stated $18000 per year was a fair price to pay. There is no money in the cure. We sell you the disease, and charge you 5x for the treatment. Fwiw I am obese.

But insurance covers most of it?

Maybe? Probably not!
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