601–610 of 1001 posts
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OP commented on a weight-loss scheme of eating every other day. Given the social attitudes around eating (which I suspect to be the #1 most common social activity), this alone has the obvious potential to eliminate ~%50 of the most likely socializing opportunities.
You can plan your fasting days around it. If you have some crazy social schedule, maybe this doesn't work. But I don't go out every night.
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FYI: GoodRX says it costs $1K/month.
The next gen lily drug is expected to cost $1500 for a 30-day supply. The US government stated $18000 per year was a fair price to pay. There is no money in the cure. We sell you the disease, and charge you 5x for the treatment. Fwiw I am obese.
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
> I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects. Are you for real? Serious question.
We're seeing the most successful Big Pharma marketing campaign since OxyContin. The Promotion and Marketing of OxyContin: Commercial Triumph, Public Health Tragedy > From 1996 to 2001, Purdue conducted more than 40 national pain-management and speaker-training conferences at resorts in Florida, Arizona, and California. More than 5000 physicians, pharmacists, and nurses attended these all-expenses-paid symposia, where…
Similarly, that Penicillin turned out to save millions of lives, doesn't mean that these drugs will be very beneficial.
Every day is a new day, every event a potential surprise...
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This is a ridiculous comment. Statistically, there is no weight loss strategy that has been found to work long term at the population level except for bariatric surgery (and now, apparently, these drugs, but we'll see how things look in a few years). Sure, one individual person can pull it off with enough willpower and support and luck. But at a population level, we know definitively that "grind it out with exercise,…
Never said I'm better. My point is that these solutions are driven by people looking for easy answers to a hard problem. I refuse to believe people need them but only want them and that may be enough for some.
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
I'm also on one of these drugs (Tirzepatide) and have been for a few months. The first time I remember knowing I was fat was when a babysitter made fun of me for it at age 6. I've been fat ever since and I'm in my late 30s now. I've lost significant amounts of weight (60+ pounds) three times in my adult life, through simple calorie restriction (intermittent fasting, including before I'd ever heard the term). Every ti…
There's something similar here I've noticed while testing myself in the past: At least for me, it seems like hunger occurs when the stomach empties by a certain percent of its last maximum. No matter if I barely eat anything, or eat until max capacity, hunger starts after my stomach empties a bit further, but it doesn't take until I'm actually empty (tested by the size of the following meal), and the hunger tends to end after reaching the last maximum. To use some made-up numbers to demonstrate, it's like I can bounce back and forth between 60% full and 90% full or 20% and 30% full, and once I've gone a cycle or two on either of those, the low ends of 60% and 20% make me feel equally hungry and the high ends of 90% and 30% equally full, but I've digested more when the baseline is on the higher end.
It can be difficult pushing from the higher range to the lower range though, have to ignore/squelch the hunger long enough to reach it.
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there's a difference between being full and feeling full. is it still known that the human body is healthy with this level of dieting and lack of nutrition? clearly can't be the case for someone who is obese so I'm wondering if this is true then if it's limited to folks who are struggling with obesity that can endure this
> there's a difference between being full and feeling full. Implying that something is off if you "feel" but are "not" full? How do you define full? Having a "healthy" amount of food in your stomach? However you define it, with asserting that, you have to acknowledge the closely related idea that there's something off if you are "full" (as you've defined it) but still not feeling full - or satiated. It's that broken…
I call it "brain hunger" and "body hunger". Over time I learned to notice the difference.
Brain hunger is just brain going "heeey, your stomach is empty, I don't like it", or "we just did a bunch , it's evening, me want tasty food as reward", or "we haven't eaten that tasty thing for a while, give food now?". The "fuck off brain, you're not hungry, you're bored" state.
Body hunger is change in physiology, not just "tummy feeing empty", my hands and legs get colder and I feel a bit more awake and on edge. And, well, annoyed.
Petro Dobromylskyj is one of the foremost experts of fat metabolism. He has a blog called Hyperlipid where he's been blogging about fat metabolism and interpreting research for close to 10 years. He thinks the GLP-1 inhibitor drugs will be a disaster in the long term because they 1) cause weight loss but also 2) cause the body to create lots of new adipocyte (fat cells). Increasing the number of adipocytes is very un…
Sounds like the opposite of a disaster for pharmaceutical companies.
Well, on the upside, the demand for this is so great that cheap generics shouldn't be too far away, right? And it seems like an insurance no-brainer to cover it for life, right?
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I'm also on one of these drugs (Tirzepatide) and have been for a few months. The first time I remember knowing I was fat was when a babysitter made fun of me for it at age 6. I've been fat ever since and I'm in my late 30s now. I've lost significant amounts of weight (60+ pounds) three times in my adult life, through simple calorie restriction (intermittent fasting, including before I'd ever heard the term). Every ti…
I have gerd, and was like, I was wondering if this would make it easier for me to eat small amounts and not have as much heartburn... then I read this: > As for side effects: I've had some heartburn, but none of the other commonly reported side effects. And I looked up the less side effects, it is a laundry list of gerd symptoms. I can confirm, these symptoms will help you lose weight, but I mean that tounge in cheek…
But intuitively it does make sense, because one of the primary effects of the drug is slowing down gastric emptying, so it causing heartburn isn't exactly surprising.
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> I expect to be on this drug long term This is a feature, not a bug. If this drug produced some kind of permanent physical change, that would be a pretty scary thing.
Erm, the intented permanent physical change for the user is establishing normal weight, at which point you would assume, that you can establish healthy routines and ideally move on without the drug. But the drug is designed (intentionally or not) in a way, that makes this very hard, keeping the user dependant on it. So I would call this a bug, but I can see people still choosing it over the alternative.