551–560 of 1001 posts
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Yes, it doesn't to you?
I think it makes sense to someone who has never tried to starve their body. Doing that will change your appreciation for the human brain.
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I would love to know what sort of healthy cut has a 6"2 male eating that low a calorie count. That is approaching weight class athlete cutting numbers which is near uniformly considered very bad for you.
If he’s not exercising and is largely sedentary then 1400 calories for an adult male is a serious deficit, but not extreme. If he added in an hour of high intensity interval training or something that would be extreme and potentially hazardous.
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
Seriously? No thanks. Think I'll give you all a few decades to see what the long-term effects are like, and let my body largely take care of itself except when specific medical issues indicate that an intervention is in order.
> “I’m really hesitant to be excited about something that I think is potentially harmful from a weight stigma perspective,” says Sarah Nutter, a psychologist at the University of Victoria in Canada, who specializes in weight stigma and body image. Putting the word "stigma" on things is a sure sign of a grifter. Instead of helping solve it, they're trying to make it a social science problem. Being overweight is unheal…
The new idea (mostly in the West) that being obese is/can be a healthy lifestyle is absolutely maddening. People being obese (and I don't mean a few pounds overweight) raises everyone's healthcare cost, because it is incredibly unhealthy and obese people tend to have more complications which requires more treatment, workers and subsidizing. It's not just an individual problem, it's a societal problem. There's a new "…
It does make sense and strikes me as irrational to celebrate something which is clearly harmful to society
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
> Losing weight was extremely challenging and socially isolating. How was it socially isolating? I’m curious because I exercise and diet and this is not my experience. I understand it being challenging though.
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I would love to know what sort of healthy cut has a 6"2 male eating that low a calorie count. That is approaching weight class athlete cutting numbers which is near uniformly considered very bad for you.
This amount of calorie would be without taking into account any exercise. Then on top of that, if you exercise (I didn't), you would just eat back the calories you consume via exercising to not be at an unhealthy level.
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
How was the process with insurance? About a year ago I tried to get on semaglutide and my insurer shut down every option. It was extremely demoralizing.
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
> I expect to be on this drug long term This is a feature, not a bug. If this drug produced some kind of permanent physical change, that would be a pretty scary thing.
But the drug is designed (intentionally or not) in a way, that makes this very hard, keeping the user dependant on it. So I would call this a bug, but I can see people still choosing it over the alternative.
At a risk of being ignorant: Isn’t obesity a function of calories intake and calories burn rate? If so, why do we even need a drug for that? What should a possible drug target here? Assuming no changes in behaviour and thus a continued steady daily caloric surplus, would it even work?
> "Sometimes the medicines most often used to treat ADHD can cause weight loss. Stimulant drugs like methylphenidate (Ritalin) and amphetamine/dextroamphetamine (Adderall) make you less hungry and make your body burn calories faster than usual. Some of them are even used to help people lose weight or treat binge eating.Oct 26, 2021"
More technically:
https://pubmed.ncbi.nlm.nih.gov/1523237/
"The effects of amphetamine on body weight and energy expenditure" (1992) Jones et. al
However, in many cases if people stop taking such drugs they can regain the weight, and the drugs can be addictive if dose regimens are not carefully managed (which doesn't seem to be a problem with ADHD). Note also these drugs are much cheaper than this new class, likely by a factor of 10.
In the long run, new behaviors (quitting alcohol and sugary foods, increasing exercise, reducing overall calorie intake, etc.) are probably needed for persistant long-term effects on reducing obesity.