‘Breakthrough’ obesity drugs that have stunned researchers

Post by rootusrootus » Wed, Jan 04, 2023, 11:02 PM UTC

0xB31B1B wrote: post #27

iammjm wrote: post #20

At a risk of being ignorant: Isn’t obesity a function of calories intake and calories burn rate? If so, why do we even need a drug for that? What should a possible drug target here? Assuming no changes in behaviour and thus a continued steady daily caloric surplus, would it even work?

These drugs modulate your hormones to reduce appetite and cravings for unhealthy foods. When people lose weight the normal way, their endocrine system sends out a “you are starving, eat” hormone response that is extremely difficult to overcome and success requires 100% compliance for the rest of your life.

Post by m_a_g » Wed, Jan 04, 2023, 11:04 PM UTC

matt3210 wrote: post #529

Convincing people to not fool around never worked so the birth control pill was invented to allow people to indulge with less consequences. I recall someone (I forget who) said that things that prevent you from eating will never work and the only solution is something that allows you to indulge without the consequences. Does this drug allow you to indulge without consequences or does it make you not want to eat? If i…

Post by SketchySeaBeast » Wed, Jan 04, 2023, 11:08 PM UTC

pixl97 wrote: post #337

fxtentacle wrote: post #224

Earlier quoted context omitted.

s/weak-willed/addicted/ There. Fixed it for you :) Yes, to me it seems like capitalism creates a society where most people get addicted just trying to cope with everyday life. For some it's alcohol, for some it's OxyContin, for some it's food, for some it's all-nighters in World of Warcraft. "59.3 million (21.4%) people over age 12 used illicit drugs in the past year." "Underage [..] 29% reported drinking alcohol" ht…

So before mass capitalism people didn't drink? Can I ask that you read a large number of history books across any number of cultures on addictive behaviors throughout history, because you'll find that anytime a society had an excess of time and labor/production that people find addictive behaviors to enjoy. This is not recent. This is not capitalism. This is humanity. What capitalism has done is given everybody enoug…

Post by kfarr » Wed, Jan 04, 2023, 11:08 PM UTC

paulpauper wrote: post #446

bioemerl wrote: post #182

> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.

Highly palatable caloric dense food means that people are more incline to gain weight without even trying. 100+ years ago you had to make a more an effort to overeat.

Post by iLoveOncall » Wed, Jan 04, 2023, 11:11 PM UTC

kasey_junk wrote: post #512

iLoveOncall wrote: post #498

Earlier quoted context omitted.

Because if you want to lose quickly, and once you get the discipline to lose you do want it to be quick, you have to restrict your calories A LOT. I'm not OP but when I was losing, as a 6"2 male, I was eating between 1200 and 1400 calories a day. This does not allow you to eat anything outside of small meals and drink anything outside of water or diet sodas. I was still going sometimes to the restaurant with friends…

I would love to know what sort of healthy cut has a 6"2 male eating that low a calorie count. That is approaching weight class athlete cutting numbers which is near uniformly considered very bad for you.