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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#441

Post by str1k3 »

dcolkitt wrote: post #328
yodsanklai wrote: post #305

Earlier quoted context omitted.

> The problem is not the food. The problem is obesity. Junk food corporations make profit by selling food, and they are extremely good at this. They rely on intense advertising, making the food addictive, targeting children. As a side effect, people get obese since they consume more calories that what they need. I don't know about GLP-1, but my intuition tells me that no drug is going to make eating Mac Donald's and…

Non-obese people who eat McDonalds and drink Coke are unequivocally healthier than obese people who adhere to the healthiest diets. There's absolutely zero academic research that disputes that obesity (and exercise) by far is the largest risk factor for diabetes, heart disease, etc.

Wow that's some impressive logical gymnastics. If these people adhere to the "healthiest diets" they will eventually no longer be obese.

American food is shit. Most people have no clue what healthy food is, even if they intend to eat a healthy diet.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#442

Post by dmix »

VikingCoder wrote: post #62
dmix wrote: post #58

Earlier quoted context omitted.

> I don't want to eat empty carbs, anywhere near as much. Because I feel like they make me feel sick. I did a keto diet obsessively for a while and I still have a psychological revulsion to drinking coke or eating cake even a year later. Those sorts of things are long term wins.

When I was trying to slowly increase my calories again, coming off of low-calorie keto, I definitely wanted coke and cake. I'm happy for you, but I didn't get that benefit you got.

Oh yeah, I wasn't really expecting it to be a general rule. I just built up "carbs = evil" so much in my head I developed a physical distaste for it, but I doubt most other people would.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#444

Post by nerdawson »

1024core wrote: post #336
smooth_remmy wrote: post #275

Petro Dobromylskyj is one of the foremost experts of fat metabolism. He has a blog called Hyperlipid where he's been blogging about fat metabolism and interpreting research for close to 10 years. He thinks the GLP-1 inhibitor drugs will be a disaster in the long term because they 1) cause weight loss but also 2) cause the body to create lots of new adipocyte (fat cells). Increasing the number of adipocytes is very un…

Given that injections cost ~ $1000/month, you're saying basically that it'll be a great recurring revenue stream for the companies. A CFO's wet dream.

I did a little bit of research and for people in the UK it appears to be substantially less. I found a few health companies offering it for <$250/mo. I’ll probably wait until it’s readily available on the NHS but it is tempting.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#445

Post by dls2016 »

watwut wrote: post #125
0xB31B1B wrote: post #86

Earlier quoted context omitted.

I mean, if you have perfect bloodwork and a marvel movie body probably not necessary but otherwise yes. Heart disease, hypertension, high cholesterol, colon cancer rates are rising amongst everyone, even thin people. These drugs positively impact indicators of these things in everyone. Longevity makers have been betting on metformin for a long time and these drugs are like a supercharged metformin

I mean yes, the obesity is actually not the only health issue in existence. Your weight and your health are two different somewhat related variables. But so, the idea that everyone should take drug designed to make you thin by making you not feel hunge including thin people is scary.

Big Pharma vs. Big Ag! Fight! Fight! Fight!

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#446

Post by paulpauper »

bioemerl wrote: post #182

> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.

Highly palatable caloric dense food means that people are more incline to gain weight without even trying. 100+ years ago you had to make a more an effort to overeat.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#447

Post by pessimizer »

buryat wrote: post #271
bioemerl wrote: post #182

> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.

people previously just couldnt grow to their natural size

This caused me uncontrollable laughter and the desire to tell everyone about it.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#448

Post by dmix »

tptacek wrote: post #181
drowsspa wrote: post #128

Earlier quoted context omitted.

I wish I got to this stage where people lose their cravings. While I'm at home I can control my diet pretty well, but as soon as there's junk food in front of me I look like a pig. And I've lost like 30 pounds, to put it into perspective.

As a data point: under carb restriction and fasting, I won't think about food at all until I happen to eat some threshold number of carbs, or I get actual hunger (shaking, weakness, headache --- usually around 20 hours in). Once I cross that carb threshold, I'll be snacky until I go to sleep. People have different metabolic situations, but if you haven't tried fasting+restriction, it's pretty interesting.

> Once I cross that carb threshold, I'll be snacky until I go to sleep.

This is where I struggled with OMAD. It's easy to not eat up to the first meal. But not snacking after dinner takes some real heart.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#449

Post by _dain_ »

fnordpiglet wrote: post #93
jobs_throwaway wrote: post #15

Earlier quoted context omitted.

Helping obese people lose weight is unidimensionally a good thing

Obese doesn’t mean unhealthy. Correlation isn’t causation. There are many obese people who are extremely healthy. I for one have had no health issues of any sort, have great blood panels, and am in decent physical condition but sit stubbornly at a 31BMI. The only “issue” I face is psychological, and it’s rooted in precisely this statement you made.

Can you run a mile? Do ten pushups?

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#450

Post by kenjackson »

wolverine876 wrote: post #405
kenjackson wrote: post #133

Earlier quoted context omitted.

Isn't all food addictive? Is there something more specific you mean about addition when it comes to these foods? It seems like it may be more about caloric density than addiction.

These foods are specifically addictive. I mean, water is addictive - I need it every three days, but that's not meaningful.

What does "specifically addictive" mean though? People keep saying it, but give no definition for it.

And you needing water every three days is meaningful. In fact, that's a great definition! Its clear what the meaning in the case of water is. I'm not sure what saying "Doritos" is addictive means? I love Doritos, but when I traveled abroad I went six months without seeing a bag and never thought of them. What exactly does "specifically addictive" mean?

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