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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

431–440 of 1001 posts

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#431

> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.

A sudden change in “natural weight” isn’t any more absurd than a sudden change in willpower.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#433

I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…

I was put on topomax for extreme migraines. Turned out a side effect was zero appetite. Unfortunately another side effect was to lose of about 60 iq points. Loved the weight loss. Missed having a brain.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#434

Earlier quoted context omitted.

The low success rates of diets suggest very hard to establish new habits

Many things are hard, but that does not mean they should not be done.

Problem with diets is that your body responds to this new habit by panicking, thinking you’re going through a famine and reduces metabolism to compensate for reduced caloric intake while increasing hunger. It’s like if you’re he body responded to brushing your teeth every day by making you obsess over caramel corn. Most habit changes don’t have this “body actively fighting you with increasing ferocity” effect that caloric restriction does.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#435
post #389
post #327

Earlier quoted context omitted.

> It's quite undeniable that modern life has drawbacks and obesity is just a symptom. Yea, people tend to forget pre-green revolution people going hungry for longer periods of time and mass starvation were really common. We made a trade, between the sudden and terrible outcome of starving and hunger to one of long term consequences like obesity and disease.

That sounds to me like a false equivalence. The cause of obesity is not that food is plentiful because different rich countries have different obesity rates. There is something else driving this issue and, in my opinion, is the prevalence of processed foods and use of highly processed seed oils.

It’s probably a combination of factors, but look at the rate of change of obesity rates. Obesity rates have been going up almost everywhere. Essentially the rest of the world has been catching up to America. America was the first country where food was so abundant that it was essentially limitless for the majority of the population.

Perhaps the effect of limitless food on obesity rates takes time to manifest and is compounded in successive generations.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#436

Earlier quoted context omitted.

The point is that you could gain back the original weight plus more. Most adults who become obese have not increased their number of fat cells - their fat cells just become larger. The GLP-1 drugs literally increase the number of fat cells.

How does liposuction fare in long term fat loss?

It's what I thought of here also. Most notably, liposuction has faired very poorly in studies of long-term health outcomes. Without the requisite changes in lifestyle or metabolism the fat that gets sucked out is replaced very quickly and has almost no decrease in risk of obesity-related illnesses.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#437
post #327

Earlier quoted context omitted.

Absolutely agree. Unironically through the first few paragraphs I though this was some very cleverly put satirical take on modern society. There is a great book about the effects of modern food, primarily on dental health, written back in the 30s - Nutrition and Physical Degeneration by Weston Price. Even though it's almost a century old, the findings are quite fascinating and can be extrapolated to present day. It's…

> It's quite undeniable that modern life has drawbacks and obesity is just a symptom. Yea, people tend to forget pre-green revolution people going hungry for longer periods of time and mass starvation were really common. We made a trade, between the sudden and terrible outcome of starving and hunger to one of long term consequences like obesity and disease.

We've gone quite far beyond never starving, we're eating far more than the required amount. Just a simple consequence of it being cheap and easy to make good tasting food by dumping sugar into literally everything. And the results are predictable.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#438
post #414

I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…

I would rather die young than deal with those side effects. And those of us who are competitive endurance athletes need the oxidative stress; it's not necessarily a bad thing depending on timing and volume. Plus we will probably find other harmful side effects after long term use. There is no free lunch when you mess around with basic metabolism; everything has a price (not just in money).

You would rather die than suffer through three months of occasional strong nausea, constipation and brainfog? I hope that's hyperbole or that you have someone to talk to.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#439

This is good news (probably?), but wanted to chime in with a tangent. Also going to preface this by saying I have struggled with weight my entire life and have lost and gained substantial weight through diet alone, always gaining it back and then some — but I think I found something that has worked for me and I have been reflecting on what I wish I was told a long time ago. It's not necessarily a problem to be "obese…

I too found this valuable, I dropped 15-20kg doing this 5 years ago and slowly put it back on due to health problems. I’ve found recently that even cardio works - if I exercise, I don’t want to waste the effort by eating shitty food, if I do have a bad day or two (Xmas period) then it feels like a bank loan I must pay off before the interest kicks in.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#440
post #289

> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.

Prior to the 20th century, it was pretty routine for average people to have inadequate access to nutrition. The rise in obesity corresponded with sweeping changed in agricultural policy that backstopped the prices of staple foods with subsidies and improved land and water management to prevent dust bowls. The result is everybody has enough food available cheaply all the time. Rolling any of that back is likely to rep…

Obesity rates started rising in the 1980's in the US, not the turn of the 20th century. This corresponds with poor diet, not abundant nutrition.
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