381–390 of 1001 posts
Earlier quoted context omitted.
Why? How many calories do you eat in a day?
None of your business. I maintain a healthy weight. Even that is none of your business. How many calories I eat does not change it being difficult to maintain.
Earlier quoted context omitted.
The only thing I see from him on google scholar is about mechanical ventilation for small animals. What's his background?
Oh man, the first result for him on Google is a link to a YouTube video. That makes my BS meter instantly peg.
Earlier quoted context omitted.
> these drugs are like a supercharged metformin No drinking alcohol, like metformin? If so, I suspect you could get a large fraction of the improvement gained from a population-wide deployment of these drugs, at zero cost , if everyone just stopped drinking alcohol. "But that's unreasonable!" Right, so if that's also required for taking this drug, then....
My whole family mostly avoids alcohol (Muslim) and lots of people are overweight.
> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.
And it makes more logical sense to you that everyone is just weak-willed?
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
I think the main problem aside from the side effects you listed is the fact that frequent injections sounds really inconvienent, and the cost is pretty prehibitive unless insurance is covering it.
Let's hope this changes and insurance companies cover it
Earlier quoted context omitted.
With every weight loss intervention when you stop you gain back the weight. GLP-1 agonists don't seem to be any different than another other intervention.
The point is that you could gain back the original weight plus more. Most adults who become obese have not increased their number of fat cells - their fat cells just become larger. The GLP-1 drugs literally increase the number of fat cells.
https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.147...
> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.
The implication is that something has happened during the last 50-100 years that caused people's "natural weight" to change upward. (Someone's "natural weight" is normally called their "set point".) The evidence is a little slim (no pun), but there's one theory which I find quite compelling. The theory is that eating foods with high flavor-calorie association increases your set point, and eating foods with low flavor…
Although I suspect there's something to your hypothesis as well. I don't know about a spoonful of oil, but I have gone through phases where food seems less "rewarding" on a physiological level, and as a result I feel more satisfied with less.
Earlier quoted context omitted.
Absolutely agree. Unironically through the first few paragraphs I though this was some very cleverly put satirical take on modern society. There is a great book about the effects of modern food, primarily on dental health, written back in the 30s - Nutrition and Physical Degeneration by Weston Price. Even though it's almost a century old, the findings are quite fascinating and can be extrapolated to present day. It's…
> It's quite undeniable that modern life has drawbacks and obesity is just a symptom. Yea, people tend to forget pre-green revolution people going hungry for longer periods of time and mass starvation were really common. We made a trade, between the sudden and terrible outcome of starving and hunger to one of long term consequences like obesity and disease.
Earlier quoted context omitted.
With every weight loss intervention when you stop you gain back the weight. GLP-1 agonists don't seem to be any different than another other intervention.
gastric bypass does not have this problem as bad