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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#371
post #339

Earlier quoted context omitted.

Why? How many calories do you eat in a day?

None of your business. I maintain a healthy weight. Even that is none of your business. How many calories I eat does not change it being difficult to maintain.

There's a whole contingent of ignorant (but smug, of course) people who like to chant "just eat less" as if that simple biological truth is the easy answer. How nice it must be for them.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#372
A class of drugs that quash hunger have shown striking results in trials and in practice. But can they help all people with obesity — and conquer weight stigma?

Who cares? Helping half of people with a problem to overcome it is great. Journalists and editors need to push back against simplistic concepts like 'one size fits all' and the urge to rank everything, which just leads to bimodal distributions and the accompanying bad outcomes when they are imposed by economic force.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#373

Earlier quoted context omitted.

You know that if you cut all sugar for just 2 days things with very little sugar will taste very sweet? We do not need the excessive amount of sugar in our food to fully enjoy it. The general public is just totally numb to it because of over consumption and companies are literally competing on having the sweater product.

This is an extreme hyperbole. While this does happen, it takes much more like 4-8w in my experience.

It's an hyperbole but not an "extreme" one. It needs some weeks instead of 2 days, but not 2 years either.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#374

Petro Dobromylskyj is one of the foremost experts of fat metabolism. He has a blog called Hyperlipid where he's been blogging about fat metabolism and interpreting research for close to 10 years. He thinks the GLP-1 inhibitor drugs will be a disaster in the long term because they 1) cause weight loss but also 2) cause the body to create lots of new adipocyte (fat cells). Increasing the number of adipocytes is very un…

I wonder how breaking old habits and establishing new habits over a year or so would stop a serious rebound?

The low success rates of diets suggest very hard to establish new habits

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#375

Earlier quoted context omitted.

[flagged]

Less cognitive load... every meal -> "will the extra serving of chicken push me over my limit?" versus "it's tuesday, no food today." "it's wednesday. Dinner time."

I get extreme brain fog after about 16 hours of no calories, reducing overall cognitive ability more than planning out two days of food compared to just one

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#376

Earlier quoted context omitted.

> If my summary is reasonably correct it seems to me what's needed is more understanding of the outcome before using drugs to "fix it". The likely reason is the changes in lifestyle thanks to the changes in technology. Is "let's just get rid of the past 70 years of technological advancement" something that we'll seriously consider?

| The likely reason is the changes in lifestyle Agreed, that's the commonly held reason but when one attempts to reverse what the changes seem to have been, by exercising more and eating less, that doesn't seem to work. My point is that perhaps we need to better understand what the changes have been, that perhaps they are more subtle than they are commonly held to be.

To couple on with what the other poster said there are two primary changes...

1. The amount of available cheap calories in convenient easy to eat packaging is orders of magnitudes higher than it was in the past.

2. Work and activity has changed so dramatically that we would not recognize the world of the past.

Now the nuance here is understanding all the small ramifications that are far more invisible to us. Think of a coke bottle and how many calories that contains, I mean it's a huge amount. But now think about the convenience of it. You can carry it with you just about anywhere. The vast majority of jobs will let you carry it around work or leave it on your desk to drink from all day. It doesn't matter how much your work out, if you drink one extra coke per day, you've added more calories in than you're working off.

But then add in all the small things that keep us from walking/exercising as much. Way fewer of our jobs are 'hard work' and been replaced by machines. We tend not to let our kids run around like wild creatures outside the house all day. Instead they are probably home, on the entertainment system of some kind with a coke in their hand. Kids also consume junk all day that is specifically marketed to them. You have to add all these factors in.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#377
post #339

Earlier quoted context omitted.

Why? How many calories do you eat in a day?

Have you ever tried to deliberately eat fewer calories every day than your body wants, for an extended period of time? Like, months and years, not days.

yes i intentionally eat healthy. I used to get breakfast smoothies and large portion breakfast and lunches. i put on weight, i cut that out and started to lose weight. i had butter with breakfast everymorning. atleast 100 calories, i noticed that was a mistake and cut it out. that isnt calories i need.

Your body wants about 1800-2200 calories. it doesnt need chips and soda and chocolate etc.. which push you above that

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#378
post #190

Earlier quoted context omitted.

And it makes more logical sense to you that everyone is just weak-willed?

It makes more sense to point to the fact that we have a far more calorie dense meal palette and a far less active lifestyle.

Pets, lab rats, and wild animals have gained weight in this timeframe.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#379
It appears you can do the same thing with 3g of cinnamon

https://pubmed.ncbi.nlm.nih.gov/19158209/

Conclusions: Ingestion of 3 g cinnamon reduced postprandial serum insulin and increased GLP-1 concentrations without significantly affecting blood glucose, GIP, the ghrelin concentration, satiety, or GER in healthy subjects.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#380

I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…

Congrats on this drug working

I lost 45 lbs myself with diet and excise, bmi is 25. Hoping it works. If it does not I at least know I have a fallback plan.

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