The headline sounds like a YouTube ad
‘Breakthrough’ obesity drugs that have stunned researchers
341–350 of 1001 posts
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#342Petro Dobromylskyj is one of the foremost experts of fat metabolism. He has a blog called Hyperlipid where he's been blogging about fat metabolism and interpreting research for close to 10 years. He thinks the GLP-1 inhibitor drugs will be a disaster in the long term because they 1) cause weight loss but also 2) cause the body to create lots of new adipocyte (fat cells). Increasing the number of adipocytes is very un…
The only thing I see from him on google scholar is about mechanical ventilation for small animals. What's his background?
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#343Earlier quoted context omitted.
Disagree. People genuinely enjoy those foods, because they're tasty and flavorful. And there's zero reason to believe that they're substantially unhealthy unless consumed to the point of sustained caloric surplus. We know this because we have hunter-gatherer populations who consume 50% of their diets in sugar (e.g. the Hadza) or fats (e.g. Intuit), and they have none of the diseases of abundance found in modern popul…
> The problem is not the food. The problem is obesity. Junk food corporations make profit by selling food, and they are extremely good at this. They rely on intense advertising, making the food addictive, targeting children. As a side effect, people get obese since they consume more calories that what they need. I don't know about GLP-1, but my intuition tells me that no drug is going to make eating Mac Donald's and…
I rarely eat junk food, and I'm fat.
Your attitude is the same as a religious person telling depressed people they need jesus rather than prozac.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#344[flagged]
How paternalistic.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#345Petro Dobromylskyj is one of the foremost experts of fat metabolism. He has a blog called Hyperlipid where he's been blogging about fat metabolism and interpreting research for close to 10 years. He thinks the GLP-1 inhibitor drugs will be a disaster in the long term because they 1) cause weight loss but also 2) cause the body to create lots of new adipocyte (fat cells). Increasing the number of adipocytes is very un…
Given that injections cost ~ $1000/month, you're saying basically that it'll be a great recurring revenue stream for the companies. A CFO's wet dream.
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Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#346> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.
There are two problems. One is that some people have a body that drives then incredibly strongly towards a certain size. The other is they there are people that given the opportunity to eat whatever they want whenever they want will slowly gain weight year after year. Gaining 3-4 pounds in a year isn't a problem and a sign that someone has a poor lifestyle. But over 2 or 3 decades, that becomes a serious problem.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#347Earlier quoted context omitted.
While we are drowning in quick to consume, non-nutritious, calories, we also have higher levels of anxiety, stress and more distractions. To your comment, maybe more countries should attempt to implement programs similar to the UK's success in lowering sodium intake by slowly adjusting the sodium content of all manufacturered foods. https://www.nature.com/articles/jhh2013105
> we also have higher levels of anxiety, stress Why should that be true? Your kids aren't going off to WW2 to die. You aren't going to starve if bugs ate your crops. You aren't going to get clubbed and robbed if you follow a forest path.
I would say our 'actual' stressors are far less, but our contrived stressors are far more.
The fact I'm not going to die tomorrow from starvation is an actual reduction in stress.
The fact that someone on the TV is screaming 24/7 that I'm going 'fucking die because THEY are out to get me' is a contrived stressor that has a real effect on everybody in society.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#348Eat less shit food and excercise more doesn't work anymore nowadays?
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#349> In the past, scientists and the public often thought that those with obesity simply lacked the willpower to lose weight. But evidence is growing that most people’s bodies have a natural size that can be hard to change. In the context where we have gone from obesity rates of 13 percent to 40, to suggest that people have a natural weight and that's the cause of this seems absurd to me.
And it makes more logical sense to you that everyone is just weak-willed?
Yes, it doesn't to you?
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#350[flagged]
Maybe losing weight the old fashioned way builds character, but so do plenty of other things. Living as a subsistence farmer also probably builds character because you’re taking an active role in producing food that maintains your body.
Instead I choose to take advantage of technology to provide food and shelter, so that I can use the extra time to focus on other pursuits.