Could S-modafinil be the new caffeine?

#1

Post by delton137 » Tue, Jan 03, 2023, 4:48 PM UTC

Could S-modafinil be the new caffeine?
moreisdifferent.substack.com

Re: Could S-modafinil be the new caffeine?

#2

Post by [deleted] » Tue, Jan 03, 2023, 4:48 PM UTC

[deleted]

Re: Could S-modafinil be the new caffeine?

#3

Post by PaulHoule » Tue, Jan 03, 2023, 4:53 PM UTC

I doubt they are separating the two enantiomers, that is very very hard to do. It seems much more likely that have a synthesis which is selective for one or the other.

Re: Could S-modafinil be the new caffeine?

#4

Post by delton137 » Tue, Jan 03, 2023, 10:14 PM UTC

PaulHoule wrote: post #3

I doubt they are separating the two enantiomers, that is very very hard to do. It seems much more likely that have a synthesis which is selective for one or the other.

Thanks, I included a footnote to elaborate on this. There's actually a paper on how Cephalon produces R-modafinil because they can't just directly synthesize one of the enantiomers. It seems the process does produce both enantiomers (but more R than S ?).. I don't fully understand the process but they have a way of crystalizing out the S enantiomer of modafinil acid and using HPLC..