41–50 of 106 posts
Do we actually know if weight loss from these medications is associated with improved health outcomes in non-diabetic people? Like does it fix joints, does it fix heart disease, blood pressure, etc?
As long as it doesn't damage those things by itself, either it will help them or we're totally wrong about what causes them.
Do we actually know if weight loss from these medications is associated with improved health outcomes in non-diabetic people? Like does it fix joints, does it fix heart disease, blood pressure, etc?
5.4 years on the drug:
Yikes. Gogo gadget thyroid tumors, not at a great place for a tumor. https://www.drugs.com/dosage/tirzepatide.html
There is some evidence that soleus push ups can induce significant insulin responses, without the need for drugs. Soleus is the muscle below the calf and normally used when walking running and jumping > All of the 600 muscles combined normally contribute only about 15% of the whole-body oxidative metabolism in the three hours after ingesting carbohydrate. Despite the fact that the soleus is only 1% the body weight, i…
Earlier quoted context omitted.
Eating better and working out is hard. If the medication can get you a similar outcome with minimal side effects, that seems like a prudent protocol to prescribe. If it’s determined to be safe (statistically), why not? Might only be necessary until we can inexpensively synthesize miR-1: https://news.ycombinator.com/item?id=34196488
Why not both? A healthy lifestyle combined with pills that work.
However, that's a big if. Behavior modification is hard. There are both physiological and emotional factors that need to be addressed, and cause many attempts at weight loss to fail.
The drugs are a second line treatment when behavior modification fails.
(And that said, exercise is still important. Overweight or not, it has a massive impact on longevity, physical health, and mental health.)
Do we actually know if weight loss from these medications is associated with improved health outcomes in non-diabetic people? Like does it fix joints, does it fix heart disease, blood pressure, etc?
Dulaglutide is a drug in the same class that has been around longer there is a modest improvement for cardiovascular events. 5.4 years on the drug: https://pubmed.ncbi.nlm.nih.gov/31189511/
I took a cursory glance at the wiki page (https://en.wikipedia.org/wiki/Tirzepatide) and it seems like it's working wonders on weight loss by targeting satiety. Weight loss still occurs when calorie out exceeds calorie input so it's not fundamentally changing anything as far as I know biochemically. Why is it so popular then? Should we be concerned about needing drugs to treat obesity? My guess is that patients who lose weight this way still needs this drug to keep it off.
Medical professionals/experts - please ream me or just correct me if I'm wrong here.
FWIW - I also struggled with weight loss. I was 284(!!!) during peak covid but managed to get myself down to 224. I'm hoping to get it down to 174 by end of this year. I found fasting + exercise + will power to be key for weight loss but I also understand that this is an anecdote and won't work for others.
Sigh, as a T2 diabetic that's been on this for a while, the lack of supply is becoming a real problem. This is in Australia, where the drug is available on the PBS for T2 Diabetes.
Obesity isn't just a cosmetic issue, it is a disease with very real health implications. If behavior modification doesn't work to lose weight, we shouldn't deny people effective treatment.
The supply chain will adjust to meet demand.