Yikes. Gogo gadget thyroid tumors, not at a great place for a tumor.
The FDA will likely approve the diabetes drug tirzepatide for weight loss
31–40 of 106 posts
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#32Here is Derek from MPMD talking about one of those diabetes 2 drugs being used for weight loss by people like Elon Musk [1] Sadly because celebrities are using these drugs I can forsee many people who are only a bit overweight taking this when just eating better and working out would be so much better for them. [1] https://youtu.be/hcNTHLdH5QE
You misunderstand how weight loss works; it's controlled by the HPA axis and various related brain/gut/pancreas/liver/fat cell interconnects, not the neocortex. "Stop eating" is an input from the neocortex. It has very, very little impact on food drive. "Satiation/Nausia" is an input from primary metabolic regulatory systems.
People that are 'only a little bit overweight' are usually in that state because they can't control their eating via the neocortex. You can't simply say "eat a little better"; you have to modify food drive. The signaling pathway this drug targets is the one that feed into food drive.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#331100-1500/month is pretty brutal. It’s a bit of a middle finger pointed at lower income people
Unfortunately it's really expensive to research and produce drugs and somebody's gotta pay for it. The rest of world isn't willing to so it looks like rich people's insurance is the one that will foot the bill which means lower income people have to wait. It sucks and it's a inefficient way to fund research but it's better than the alternative where no one funds this research and we (both rich and poor) never get the…
Another alternative is the government funding this research and/or buying the drug directly. This is what was done for the government ordering 30 billion dollars worth of covid vaccines from moderna, pfizer, and j&j.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#34Drugs like Adderall don't mimic the hormones talked about in the article, right? I took Adderall XR once a day in college which completely suppressed my appetite and, combined with being a poor student that couldn't always afford lunch, I would frequently only eat one meal a day (either breakfast or dinner.) Since I graduated college many years ago, I also stopped taking Adderall but my sense of hunger has never retu…
> Adderall increases the level of serotonin in your body, which can cause your appetite to decrease, leading to weight loss. This can be a good thing if you are trying to lose weight, but it can also cause stomach pain.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#35Drugs like Adderall don't mimic the hormones talked about in the article, right? I took Adderall XR once a day in college which completely suppressed my appetite and, combined with being a poor student that couldn't always afford lunch, I would frequently only eat one meal a day (either breakfast or dinner.) Since I graduated college many years ago, I also stopped taking Adderall but my sense of hunger has never retu…
There's a lot we don't know, but from what I gather microbiome tends somewhat towards homeostasis such that you tend to eat in a way that maintains the current status quo. Among other things, this is linked to things like whether or not you are at risk for obesity.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#36Drugs like Adderall don't mimic the hormones talked about in the article, right? I took Adderall XR once a day in college which completely suppressed my appetite and, combined with being a poor student that couldn't always afford lunch, I would frequently only eat one meal a day (either breakfast or dinner.) Since I graduated college many years ago, I also stopped taking Adderall but my sense of hunger has never retu…
Low metabolism perhaps?
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#37Drugs like Adderall don't mimic the hormones talked about in the article, right? I took Adderall XR once a day in college which completely suppressed my appetite and, combined with being a poor student that couldn't always afford lunch, I would frequently only eat one meal a day (either breakfast or dinner.) Since I graduated college many years ago, I also stopped taking Adderall but my sense of hunger has never retu…
Low metabolism perhaps?
Low metabolism tends to cause weight gain, so probably not. Iirc, people with low metabolism eat more to get their energy levels and/or temp up high enough until their weight gain brings up their metabolism to a more normal range.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#38Here is Derek from MPMD talking about one of those diabetes 2 drugs being used for weight loss by people like Elon Musk [1] Sadly because celebrities are using these drugs I can forsee many people who are only a bit overweight taking this when just eating better and working out would be so much better for them. [1] https://youtu.be/hcNTHLdH5QE
You misunderstand how weight loss works; it's controlled by the HPA axis and various related brain/gut/pancreas/liver/fat cell interconnects, not the neocortex. "Stop eating" is an input from the neocortex. It has very, very little impact on food drive. "Satiation/Nausia" is an input from primary metabolic regulatory systems. People that are 'only a little bit overweight' are usually in that state because they can't…
Eating better effects satiety.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#39Do we actually know if weight loss from these medications is associated with improved health outcomes in non-diabetic people? Like does it fix joints, does it fix heart disease, blood pressure, etc?
As long as it doesn't damage those things by itself, either it will help them or we're totally wrong about what causes them.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#40Drugs like Adderall don't mimic the hormones talked about in the article, right? I took Adderall XR once a day in college which completely suppressed my appetite and, combined with being a poor student that couldn't always afford lunch, I would frequently only eat one meal a day (either breakfast or dinner.) Since I graduated college many years ago, I also stopped taking Adderall but my sense of hunger has never retu…
> Adderall increases the level of serotonin in your body, which can cause your appetite to decrease, leading to weight loss. This can be a good thing if you are trying to lose weight, but it can also cause stomach pain.
Adderall and other stimulants activate the chemoreceptor trigger zone in the brain and that can mediate feelings of hunger, nausea, trigger vomiting etc.