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The FDA will likely approve the diabetes drug tirzepatide for weight loss

nbcnews.com

21–30 of 106 posts

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#21

1100-1500/month is pretty brutal. It’s a bit of a middle finger pointed at lower income people

Unfortunately it's really expensive to research and produce drugs and somebody's gotta pay for it. The rest of world isn't willing to so it looks like rich people's insurance is the one that will foot the bill which means lower income people have to wait.

It sucks and it's a inefficient way to fund research but it's better than the alternative where no one funds this research and we (both rich and poor) never get the drug.

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#22

Drugs like Adderall don't mimic the hormones talked about in the article, right? I took Adderall XR once a day in college which completely suppressed my appetite and, combined with being a poor student that couldn't always afford lunch, I would frequently only eat one meal a day (either breakfast or dinner.) Since I graduated college many years ago, I also stopped taking Adderall but my sense of hunger has never retu…

No Adderall works via a completely different pathway.

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#23

1100-1500/month is pretty brutal. It’s a bit of a middle finger pointed at lower income people

You can get these wholesale from China from "reputable" gray-market wholesalers who get the chemicals made at contract manufacturing facilities. Independent purity tests via HPLC are available for If an annual amount is purchased on the gray market, this brings the monthly cost down to:

- Tirzepatide: $60/month

- Semaglutide: $10/month

- Liraglutide: $87/month

Note that in the USA, it is legal to import certain amounts of FDA-approved drugs if you have a prescription for them. However, just because something is the exact same chemical as an FDA-approved drug does not make it an FDA-approved drug. It must be manufactured in an FDA certified facility and be the same brand/manufacturer/packaging/labeling/etc as the approved drug.

e.g. importing generic Sildenafil/Viagra is legal if you can find the Teva(tm) brand generic sildenafil in, say, Mexico or Canada for a better price. But it must be the pills manufactured by Teva in the appropriate facility with NDC #0093-5342-56[0]. If you import generic sildenafil "Cenforce" from the (very legitimate but not FDA-approved) Indian pharmaceutical manufacturer "Centurion Laboratories"...

...that would still be potentially criminal smuggling. Even if the pills you import show via laboratory test that they precisely match your medical prescription, they are not "FDA approved" and therefore not legal to import.

A lot of people do though!

0: https://ndclist.com/ndc/0093-5342/package/0093-5342-56

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#24

1100-1500/month is pretty brutal. It’s a bit of a middle finger pointed at lower income people

Lower income people of 2036 and beyond will have a magical medicine for probably 30 bucks a month.

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#26

Here is Derek from MPMD talking about one of those diabetes 2 drugs being used for weight loss by people like Elon Musk [1] Sadly because celebrities are using these drugs I can forsee many people who are only a bit overweight taking this when just eating better and working out would be so much better for them. [1] https://youtu.be/hcNTHLdH5QE

If your BMI is over 35 (around 1 in 6 adults IIRC) it can make it hard to exercise. A little push in the right direction may be indicated.

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#27
post #19

There is some evidence that soleus push ups can induce significant insulin responses, without the need for drugs. Soleus is the muscle below the calf and normally used when walking running and jumping > All of the 600 muscles combined normally contribute only about 15% of the whole-body oxidative metabolism in the three hours after ingesting carbohydrate. Despite the fact that the soleus is only 1% the body weight, i…

Possibly related: Insulin resistance is impacted by muscle protein.

https://news.ycombinator.com/item?id=14667430

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#28

1100-1500/month is pretty brutal. It’s a bit of a middle finger pointed at lower income people

Lower income people of 2036 and beyond will have a magical medicine for probably 30 bucks a month.

It will be too little too late for many by then

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#29

Earlier quoted context omitted.

Eating better and working out is hard. If the medication can get you a similar outcome with minimal side effects, that seems like a prudent protocol to prescribe. If it’s determined to be safe (statistically), why not? Might only be necessary until we can inexpensively synthesize miR-1: https://news.ycombinator.com/item?id=34196488

Unfortunately there aren't any shortcuts to good health

If you’re regularly doing something unhealthy (like smoking or eating lead paint chips), stopping that is both good for you and a shortcut.

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#30
post #26

Here is Derek from MPMD talking about one of those diabetes 2 drugs being used for weight loss by people like Elon Musk [1] Sadly because celebrities are using these drugs I can forsee many people who are only a bit overweight taking this when just eating better and working out would be so much better for them. [1] https://youtu.be/hcNTHLdH5QE

If your BMI is over 35 (around 1 in 6 adults IIRC) it can make it hard to exercise. A little push in the right direction may be indicated.

Exercise is also counterproductive for weight loss since it makes you hungrier, which makes people not compliant with their diets.
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