Earlier quoted context omitted.
Personally, I'd remove tRPC on down (and choose a database). It's nice there's type-safety between layers, but that's a bunch of layers that you don't even need. (A layer that doesn't exist takes is 100% type-safe and takes 0 hours to develop and maintain).
> A layer that doesn't exist takes is 100% type-safe How are you ensuring your database accesses are type-safe in this case?
So I can't really claim I have nothing at the ORM level... However...
In my experience, when you pull in an off-the-shelf ORM and an off-the-shelf RPC framework you end up building app-level wrappers anyway to deal with the complexity and impedance mismatch between what you want your app to use for data access code and what layer provides.
So I think you might as well put your app-level database wrapper as directly around the database as you can manage (that probably means using the common, unopinionated client for your db... e.g., node-postgres for server-side javascript and postgres, or whatever the equivalent is for your backend/database).