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What causes Alzheimer's? Scientists are rethinking the answer
231–240 of 243 posts
Re: What causes Alzheimer's? Scientists are rethinking the answer
#232Carbs cause Alzheimers. As you age, your insulin resistance rises, but you still eat the same amount (or more) of carbs while simultaneously exercising far less.
Eat a ketogenic diet and you don't have to worry about Alzheimers.
Re: What causes Alzheimer's? Scientists are rethinking the answer
#233Carbs cause Alzheimers. As you age, your insulin resistance rises, but you still eat the same amount (or more) of carbs while simultaneously exercising far less. Eat a ketogenic diet and you don't have to worry about Alzheimers.
Citation? This kind of study will take at least three quarters of a century to reach such clear cut conclusions. I don't think people hanging on to pseudoscientific BS live long enough to worry about Alzheimers.
Re: What causes Alzheimer's? Scientists are rethinking the answer
#234Earlier quoted context omitted.
The thing with eating and sleeping right etc is that we know the limits of it: it can keep you alive into your 90's at best, and more realistically into your 80's. Technology on the other hand is completely uncapped. A pill that keeps a degenerate bum alive into the 80's might be really hard to achieve, but the kicker is that once you do, it's just another step or two to keeping him alive until 200.
Not to state the obvious, but old people are really, well, old (and frail). Your pill would need to do a lot of heavy lifting. I'm no doctor, but your pill would need to deal with mental issues (dementia of all kinds etc) and physical issues, like muscle mass, bone density, flexibility, skin elasticity and lots more. There are very few, dare I say no, 90 year old that could pass for 70 - what sort of condition would…
It would likely not be a pill, but a therapy replenishing stem cells, the immune system etc.
The frailty comes from somewhere, like depletion of certain stem cells that produce new tissue.
Re: What causes Alzheimer's? Scientists are rethinking the answer
#235Earlier quoted context omitted.
Disturbed sleep should IMO also be looked at - eg UARS and sleep apnea. You can sleep 8h every night and still feel crappy waking up. Maybe disturbed sleep is even worse than lack of sleep? I can feel better after 6h of good sleep than after 9h of disrupted sleep (eg when I know I‘ve been snoring, eg due to throat infection).
The link isn't "disturbed sleep" necessarily. As we age, sleep naturally degrades, and that degradation is in the slow-wave sleep which drives the clearing of amyloid plaques, and tau (along with hormonal response, memory consolidation, nervous system, and more). The technology we're developing at https://soundmind.co is supporting an Alzheimer's prevention trial beginning in January '23 which is looking at the impac…
By your argument, everybody would get Alzheimer‘s sooner or later. But most old people (still) don’t.
Re: What causes Alzheimer's? Scientists are rethinking the answer
#236Re: What causes Alzheimer's? Scientists are rethinking the answer
#237Earlier quoted context omitted.
No, we need cities and towns that are designed around active transport. Exercise should not be a "thing you do", it should just be part of life. If you want to "do exercise" it needs to be in addition to the normal every day base level of exercise everyone gets for free. That said, you don't need to wait to be given those opportunities. Look for every opportunity for unnecessary expenditure of energy - you'll find th…
Basically Singapore. Unfortunately that country can't be model in any western countries due Chinese inherent concept of devine right to rule (mandate from heaven). The system depends on people believing in a single party in overwhelming majority (>65%) and mandatory voting. Western countries depends on majority of voters being lazy and bot involved and let a small subset of vocal minority to control the government wi…
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Re: What causes Alzheimer's? Scientists are rethinking the answer
#238I think there's a social element to it. My mother's cognition fell off a cliff with the social isolation during covid. Also, she has lifetime poor hearing
"... mild hearing loss doubled dementia risk. Moderate loss tripled risk, and people with a severe hearing impairment were five times more likely to develop dementia".
https://www.hopkinsmedicine.org/health/wellness-and-preventi...
Re: What causes Alzheimer's? Scientists are rethinking the answer
#239Earlier quoted context omitted.
The link isn't "disturbed sleep" necessarily. As we age, sleep naturally degrades, and that degradation is in the slow-wave sleep which drives the clearing of amyloid plaques, and tau (along with hormonal response, memory consolidation, nervous system, and more). The technology we're developing at https://soundmind.co is supporting an Alzheimer's prevention trial beginning in January '23 which is looking at the impac…
By your argument, everybody would get Alzheimer‘s sooner or later. But most old people (still) don’t.
Not necessarily. Though Alzheimer's is an age related disease, and each 5 years increases the likelihood of developing Alzheimer's [1].
The older you get, the more likely you are to get Alzheimer's. Young people don't get Alzheimer's (with the exception of early onset, which is still in an older population).
So if we extend life long enough, will everyone get it?
Unlikely. Just like not everyone with high cholesterol develop heart disease. However the older we get, the worse sleep gets, the more build up of amyloids, the more likely a person is to develop Alzheimer's.
Part of the reason the amyloid theory is in question is because there are people with significant build up of amyloid who do not develop Alzheimer's and there are people with little amyloid build up who do generate Alzheimer's.
[1] https://www.nia.nih.gov/health/what-causes-alzheimers-diseas....
Re: What causes Alzheimer's? Scientists are rethinking the answer
#240Earlier quoted context omitted.
Nobody gets a K award on their own merits. Unless your mentoring committee is well funded and walking lockstep with conventional wisdom, your application is dead in the water.
That's the sad part. Albeit one of my colleagues I know (immensely talented in his own right) is also extremely good is sniffing out who's on the NIH study section reviewing his grants, and networking with them after hours...
Study section rosters are published information. Membership is set for a period of years. Interfering with members is expressly forbidden, though no doubt it happens.