Earlier quoted context omitted.
I don't think "genocide" is the right term here. It is part of a wider man-made famine, which is an act of great evil perpetrated by the communist regime, but it affected all parts of the southern USSR, including areas with mainly ethnic Russian populations. For more information, you may want to read more about the policies that led to this event, such as "dekulakization"
I am aware that genocide is a disputed term in this context. I lean towards it because the famine disproportionately affected Ukrainians (and Kazakhs) and was at least in part not mitigated intentionally to punish minorities with a stronger anti-Soviet sentiment.
But, of course, this possibility does not exclude the other. If this was the primary motivation, however, it neatly explains why some southern Russian regions were also severely affected despite not having any separatist tendencies.