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What causes Alzheimer's? Scientists are rethinking the answer

quantamagazine.org

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Re: What causes Alzheimer's? Scientists are rethinking the answer

#32
The brain "takes out the trash" when you sleep.* From what I have read, the accumulation of both amyloid beta and tau are linked to sleep deprivation. They may be markers of sleep deprivation and treating the sleep deprivation may be the best thing to do, though that probably won't get someone famous for some billion dollar drug discovery, so no one will likely pursue it.

(Yes, I am aware that some of the research is possibly fraud, other avenues of investigation have been suppressed, etc. I've read quite a few articles about Alzheimer's, my late father had Alzheimer's and ...etc.)

* https://news.ycombinator.com/item?id=25427090

Re: What causes Alzheimer's? Scientists are rethinking the answer

#34
post #5

In many scientific research projects the same dangerous theme keeps surfacing: monolithic thinking, with “no alternatives allowed”. I feel this is very detrimental to both scientific progress as well as to the broader society.

You'd think that after a decade of failed results, someone would go back to the drawing board and start again. But it never seems to happen.

We have only recently had any drugs that could reduce the beta amyloid. While they do reduce the amyloid, they do not see to have an equivalent impact on the actual disease. That failure IS prompting people to reconsider other root causes, again.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#35

Has anyone noticed that Alzheimer’s research tend to hit the front page much more than other medical news? I’ve been wondering why for a while.

From the comment right below yours:

> As someone who has a close relative diagnosed with this disease, I'm always on the lookout for new information. So this is interesting.

AD is, sadly, rather common, as well as a really devastating disease: you can do nothing but watch as your loved ones become shells of themselves in front of your eyes. You can consider yourself lucky for not having gone through it personally.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#36

As someone who has a close relative diagnosed with this disease, I'm always on the lookout for new information. So this is interesting. One area I'm particularly interested in is the correlation to diabetes. It's a factor that I found being mentioned here and there in some references. In the immediate case that interests me, there's a 20+ year history of type 2 diabetes and a recent scan showed severe bilateral hypoc…

From the article: "A report in the July 2020 issue of The Lancet listed the variety of known risk factors for dementia, ranging from air pollution to repetitive head trauma to systemic infections." The article doesn't mention diabetes or sugar.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#37

As someone who has a close relative diagnosed with this disease, I'm always on the lookout for new information. So this is interesting. One area I'm particularly interested in is the correlation to diabetes. It's a factor that I found being mentioned here and there in some references. In the immediate case that interests me, there's a 20+ year history of type 2 diabetes and a recent scan showed severe bilateral hypoc…

> One area I'm particularly interested in is the correlation to diabetes. Sugar. I think the correlation is more so to sugar. I too had a loved one with Alzheimer’s, and there was definitely strong reason to believe sugar was a contributing factor.

I consume a lot of sugar. I’m not diabetic or pre diabetic. I would suspect underlying inflammation leads to some nasty effects. The same for heart disease.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#39

Has anyone noticed that Alzheimer’s research tend to hit the front page much more than other medical news? I’ve been wondering why for a while.

Seems rational that there would be so much interest in a devastating, widespread malady that's cause is not well understood.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#40
post #33

Has anyone noticed that Alzheimer’s research tend to hit the front page much more than other medical news? I’ve been wondering why for a while.

Is one of the five or six big medical problems of our time.

You are probably right. How would a list look like? In no particular order, perhaps:

Cancer ALS Alzheimer Diabetes Covid AIDS

?

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