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In many scientific research projects the same dangerous theme keeps surfacing: monolithic thinking, with “no alternatives allowed”. I feel this is very detrimental to both scientific progress as well as to the broader society.
One area I'm particularly interested in is the correlation to diabetes. It's a factor that I found being mentioned here and there in some references. In the immediate case that interests me, there's a 20+ year history of type 2 diabetes and a recent scan showed severe bilateral hypocampal atrophy. When googling for a link between the two I found this: "Lower insulin secretion was significantly associated with HPGA (hippocampal and parahippocampal gyrus atrophy) in patients with type 2 diabetes mellitus. The results of this study support the hypothesis that insulin‐signaling abnormalities are involved in the pathophysiology of Alzheimer’s disease." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504906/
Yet, the mechanism of this, if indeed there's causality (not just correlation) does not seem to be known.
In many scientific research projects the same dangerous theme keeps surfacing: monolithic thinking, with “no alternatives allowed”. I feel this is very detrimental to both scientific progress as well as to the broader society.
In any case the whole amyloid system is involved somehow, I think that much is very likely. Just not in the way that the visible amyloid fibers are the cause, but might just be another symptom. This is not anything like heretical talk, this suspicion was pretty much mainstream when I studied biochemistry ~15 years ago. It was only a hypothesis, but it certainly wasn't suppressed.
Was there ever an examination of this[1]? I'm somewhat confused about how such a long article never mentioned it... [1]: https://www.theguardian.com/society/2022/jul/23/alzheimers-s...
"The hypothesis took another hit last July when a bombshell article in Science revealed that data in the influential 2006 Nature paper linking amyloid plaques to cognitive symptoms of Alzheimer’s disease may have been fabricated. The connection claimed by the paper had convinced many researchers to keep pursuing amyloid theories at the time. For many of them, the new exposé created a “big dent” in the amyloid theory, Patira said."
As someone who has a close relative diagnosed with this disease, I'm always on the lookout for new information. So this is interesting. One area I'm particularly interested in is the correlation to diabetes. It's a factor that I found being mentioned here and there in some references. In the immediate case that interests me, there's a 20+ year history of type 2 diabetes and a recent scan showed severe bilateral hypoc…
could be prions from eating meat, could be genetic... it's likely similar to "what causes cancer?"