I’m probably not as talented as the author, but I can’t relate to this feeling of giving up because some work won’t be used. I have been working for ten years post-PhD and every single product I’ve ever worked on has been canned, sometimes very circuitously via acquisitions. My work is trade secret so I’ve never filed a patent, written a publication, nor given a talk. I have zero outwardly observable accomplishments.…
People are fulfilled by different things. Some people are far more interested in their working having a meaningful (to them) impact to the "outside" world than the specifics of the work.