Earlier quoted context omitted.
I would understand your argument if you were talking about more constrained systems, but RPIs have GOBS of storage and memory. A 45mb executable vs 7mb executable is totally negligible.
It is not about binary size per se, but of features/binary ratio. Can Cobalt run, say, ChartJS as it is ( https://sciter.com/chartjs-in-sciter/ )? Seems like not as I do not see in the list of its supported elements.
Features which the project actually needs will be decisive.
Does the project need Canvas? Sciter is the better choice.
Does the project need CSS Flexbox? Cobalt will be a better fit.
The binary size may play a role if all else is equal ...