A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

Post by empiricus » Sun, Nov 13, 2022, 5:21 PM UTC

drowsspa wrote: post #19

bugfix-66 wrote: post #17

Earlier quoted context omitted.

We have an old, safe, cheap drug for humans already: Metformin. Most people can get an off-label metformin prescription for anti-aging or appetite suppression. Your interest in food will be reduced to the point you have trouble keeping weight on. Sugar will be repulsive to you. Sweet food tastes "sickly sweet", nauseating. Metformin also interferes with the absorption of carbohydrates in your gut.

I once heard about one drug that basically works by making you nauseous to food. Is it the one? > Metformin is generally safe, but common side effects do include vomiting, nausea, and diarrhea. Those experiencing these unpleasant side effects might consume less food, resulting in modest weight reductions.

Post by bollu » Sun, Nov 13, 2022, 5:26 PM UTC

adrian_b wrote: post #37

sigg3 wrote: post #31

Earlier quoted context omitted.

> What I've found is that matters is appetite: some people just get full way faster than others. This is a half truth. If you cut down portion size your stomach will shrink over time. I eat a lot less before feeling full now, and I only changed my life a year ago. It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now…

For increased satiety, even when eating little, an additional factor is that the food should not be too soft, like most of the industrially made food is, but it should need some time of vigorous chewing. There are many vegetables, fruits and nuts that require a decent amount of chewing. There are also some kinds of home-made bread that require much more chewing than the industrial soft bread, while also being much ta…

Post by hanniabu » Sun, Nov 13, 2022, 5:28 PM UTC

socialismisok wrote: post #2

I'd love to have some help with this. I was able to drop meat, most dairy, and salty junk food without problem. I eat plenty of green leafy vegetables. But sugar. Fuuuck I cannot walk past sweets. Sugar has claws in me I cannot shake. I hope we someday understand that mechanism better, maybe enough to give me a little help.

Post by guerrilla » Sun, Nov 13, 2022, 5:35 PM UTC

sigg3 wrote: post #31

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

> What I've found is that matters is appetite: some people just get full way faster than others. This is a half truth. If you cut down portion size your stomach will shrink over time. I eat a lot less before feeling full now, and I only changed my life a year ago. It's also important that you eat stuff that makes you feel full, fibers and greens. Changing diet also changed my taste, so I crave more healthy things now…

Post by bugfix-66 » Sun, Nov 13, 2022, 5:40 PM UTC

smhoff256 wrote: post #64

bugfix-66 wrote: post #17

Earlier quoted context omitted.

We have an old, safe, cheap drug for humans already: Metformin. Most people can get an off-label metformin prescription for anti-aging or appetite suppression. Your interest in food will be reduced to the point you have trouble keeping weight on. Sugar will be repulsive to you. Sweet food tastes "sickly sweet", nauseating. Metformin also interferes with the absorption of carbohydrates in your gut.

I think those kinds of blanket statements about metformin are a little misleading and a bit dangerous. For instance I myself have been on metformin now for almost 2 years and I can assure you I have no repulsion to sugar.