> The only way out is to break the chain of elevating mental isolation and negativity.
How exactly to do that is the tricky part, though (and not just tricky for individuals, but the subject of much debate in psychiatry). Possibilities include pharmacological intervention, therapy, or some sort of change in circumstances. The latter is a really large set of options, but also poorly understood: there are semi-regular reports of people completely changing outlook after significant changes in circumstances (e.g. changing careers), but it's very hard to come up with rigorous evaluation of the success of that "treatment option", because it's not very easy to run a controlled study, and not always an available option.