My friend figured out for herself, when she was in her 30's, that she's a poor methylator who can't turn the food fortification folic acid into a usable form of Vitamin B-9. She once told me that adding L-Methylfolate to her routine was like flipping a switch from "depressed" to "not-depressed". But the doctors had already decided she was being "stabilized" by the anti-psychotic prescriptions they forced on her, so they just added this vitamin to their cocktail of prescriptions.
Vitamin B-9 has to do with DNA synthesis... My source for physiology told me that even the mutants get enough Vitamin B-9 from an adequate diet, it's just poor methylators who rely on fortified food who are screwed. Deplin is the prescription form of Vitamin B-9. It's approved as an add-on therapy, for when patients don't respond well to the prescriptions that never work.
Usually 'mental health' diagnoses are manifestations of stress: emotional stress is the big one, but malnourishment is often a factor too. Stressed brains use more energy thinking about the stress all the time.
ECT should be retired from use. I heard once that brain damage causes the brain to increase production of the steroid allopregnanolone. The beneficial effect of the SSRI's seem to also be related to increased allopregnanolone, NOT to boosting serotonin levels.
I wonder if my friend's guardian [0] could consent to her getting electrocuted.
[0] https://news.ycombinator.com/item?id=33307982
Edit: She remembers being depressed for as far back as her memories go. Someone on twitter says food fortification didn't really take off until the 1980's. Before then you had to explicitly buy "wonder bread" to get fortified flour, now you can basically assume white flour is fortified white flour.