Earlier quoted context omitted.
Do you have a response to Gary Taubes et al. who have observed in recent years that the "calories in vs. calories out" hypothesis has no basis in the science of human metabolism, and that insulin, the hormone secreted in response to consumption of carbohydrates, has a very well-understood and primary role in fat storage?
You might want to read the conclusion (last paragraph) here, then go back and read how Stephan arrived at it: http://wholehealthsource.blogspot.com/2011/08/carbohydrate-h...
Really, as someone who very easily went from overweight to fit purely by replacing carbs with fats, I'm just very reluctant to accept the thermodynamic hypothesis.