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The Degradation Drug

theamericanscholar.org

41–50 of 79 posts

Re: The Degradation Drug

#41

> euthanized her cat on a whim. this is the scary bit. Killing animals for fun is how many serial killers get started.

It's not really clear how she euthanized her cat. That would seem pretty important.

True. Also whether she previously “felt sorry” for the cat for some reason, maybe it was sick and suffering and the drug just switched her mind.

Re: The Degradation Drug

#42
I read in body building forums that those who are on testosterone take cabergolin to keep their male breast from changing too much.

Some of them said it made them more sexually active than before. They got horny more often and the refractory period was reduced.

When I read about caber, I found out it was given to Parkinson patients and that one of it main side effects was that people were more inclined to gamble and have sex.

Re: The Degradation Drug

#43
post #9
post #2

> But soon his euphoria was accompanied by an insatiable libido. Leonard became a “wild, wonderful, ravening man-beast,” masturbating for hours on end. Is going for a few hours unusual? If so, I've been in big trouble ever since I turned 14.. (now going on 39) It just feels really good. Hmm.

Not really the place to display your kink, man. Plenty of dedicated spaces on the Internet for that - a space being dedicated to sexual activity greatly increases the chance that a user consents to seeing that sort of content. But if lack of consent is what you're going for, then please explore CBT options for moderating that behavior.

>Not really the place to display your kink, man.

Masterbating for hours isn't a kink. What you masterbate to, is. And "man"? Could be female.

Re: The Degradation Drug

#44
post #12

Earlier quoted context omitted.

I agree about it sounding like a manic episode a lot. If I were to put up an opposing opinion -- some caveats here: cluster B disorders and autism both can include lithium (and symptoms not too dissimilar from mania), lamotrigine too on the BPD front. Mood stabilizers are prescribed in combination for a variety of conditions, I feel like it's a rather large jump to make. Also, Moda and a Benzodiazepine are going to d…

I omitted the Xanax entirely from my previous post because the polypharmacy here is such a mess, but I agree that it probably factors into disinhibition. I don't personally attribute much relevance to modafinil in this instance; while the wakefulness effects are often described mechanistically through dopamine, I have never seen anyone experience any traditional stimulant or dopamine agonist effects from modafinil. M…

Modafinil is disruptive to the circadian rhythm, which can exacerbate mania. It won't push dopamine on its own but in combination I'm sure it contributed, especially if, as is common with mania (which this article clearly describes without naming it, which is shameful frankly), she started taking her meds whenever she felt like it, instead of on a schedule.

Re: The Degradation Drug

#45
post #14

The article describes its first subject as having been diagnosed with simply "depression", but describes their medication regime as including lithium and lamotrigine which in combination is strongly suggestive of treatment for bipolar depression in particular. Given that the described behavior sounds very much like a manic episode, the article should have explained this connection before attempting to focus the blame…

Sounds like this behavior change lasted for years though. That is one hell of a manic episode. (Also, key question, was the art any good?)

Also, she said that the excessive stimulation disappeared after she stopped taking the drug.

Re: The Degradation Drug

#46
post #12

The article describes its first subject as having been diagnosed with simply "depression", but describes their medication regime as including lithium and lamotrigine which in combination is strongly suggestive of treatment for bipolar depression in particular. Given that the described behavior sounds very much like a manic episode, the article should have explained this connection before attempting to focus the blame…

I agree about it sounding like a manic episode a lot. If I were to put up an opposing opinion -- some caveats here: cluster B disorders and autism both can include lithium (and symptoms not too dissimilar from mania), lamotrigine too on the BPD front. Mood stabilizers are prescribed in combination for a variety of conditions, I feel like it's a rather large jump to make. Also, Moda and a Benzodiazepine are going to d…

Would you be able to write more about dopamine agonists "screw[ing] some things up about you semi-permanently?"

I was on them for RLS for a while. I had even started taking L-DOPA, when pramipexole/ropinirole/gabapentin/etc. were negatively affecting my quality of life. However, the L-DOPA triggered some very, in-hindsight but unfortunately never during, terrible personality changes. One of which decided that it was prudent to keep upping my L-DOPA dosage, become a severe poly-substance abuser, and all-around just make a huge mess of my life.

I may also be recovering from nerve damage in my legs and feet from this escapade (either from the L-DOPA causing oxidative damage/receptor over-excitement and death -- or from the litany of other substances). I may have also unknowingly "semi-permanently" down-regulated my AAAH (?) enzymes, leading to effects I cannot even imagine.

Re: The Degradation Drug

#47

It seems to me that issues like this one expose a fundamental flaw with how criminal justice is generally practiced - one that's evident in the term itself. The focus is on assigning blame and just (fair) punishment. ISTM a better framing might be to determine the desired outcome and how best to achieve it. How likely is someone to re-offend, and what is the best intervention to reduce that likelihood? In the most ex…

> The focus is on assigning blame and just (fair) punishment. ISTM a better framing might be to determine the desired outcome and how best to achieve it. How likely is someone to re-offend, and what is the best intervention to reduce that likelihood?

That would be rational, and, especially in the US, our criminal justice system very rarely intersects with rationality. In general, it's based on what will provide the most extreme emotional response among voters.

Re: The Degradation Drug

#49
Mesmerizing read.

I found it very relatable because as a person trying to manage ADHD those experienced traits and behaviors during treatments are very similar to my untreated ones.

I keep my dark side "on the leash" and maybe it's not as vibrant as ones in story (probably because I was born with it and had chance to adjust over years) but some similarities are uncanny.

With various treatment experiences I had I start to believe that there is no "I" in anyone. It's just an effect of a brain chemistry on which we have very limited effect. Identity that's effect of trauma or treatment is just as real as the one we were born with.

Ethical implications are very interesting, but in reality I doubt anything will change until we have a breakthrough in neurosciences. Even then probably there would be question if we should equalize people different. Feels like a plot for sci-fi movie - there even was one like that: https://www.imdb.com/title/tt0238380/

Re: The Degradation Drug

#50
post #12

The article describes its first subject as having been diagnosed with simply "depression", but describes their medication regime as including lithium and lamotrigine which in combination is strongly suggestive of treatment for bipolar depression in particular. Given that the described behavior sounds very much like a manic episode, the article should have explained this connection before attempting to focus the blame…

I agree about it sounding like a manic episode a lot. If I were to put up an opposing opinion -- some caveats here: cluster B disorders and autism both can include lithium (and symptoms not too dissimilar from mania), lamotrigine too on the BPD front. Mood stabilizers are prescribed in combination for a variety of conditions, I feel like it's a rather large jump to make. Also, Moda and a Benzodiazepine are going to d…

I've been tried on lithium and lamotrigine for treatment-resistant depression in the past. It doesn't necessarily indicate bipolar disorder.

I'm floored by the combo of modafinil and xanax. Adding pramipexole to the mix seems insane to me. I'm prescribed modafinil for narcolepsy and depending in the dose, it can sure make you look hypomanic just taken by itself. I had a very productive month after having to go off armodafinil for 2 weeks prior to a sleep study. My exhausted self didn't even think to taper back up to the old dose and went straight back to 250mg. My psych initially diagnosed it as hypomania. Turned out it was just way too high of a dose after losing my tolerance.

I'm no psych, but those 3 meds prescribed together seem like borderline malpractice to me.

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