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Do fungi lurking inside cancers speed their growth?

nature.com

31–40 of 87 posts

Re: Do fungi lurking inside cancers speed their growth?

#31

Earlier quoted context omitted.

Or tricked into worrying about that as a control signal to perform its main task in service of its microorganism operators ;)

Nobody in this thread has read Selfish Gene, apparently. That's the whole point of the book: That genes may as well have invented all of life to propagate themselves. In this context, species conflict is like fleets of world-ships fighting total war.

Genes are effectively biological computer programs.

Re: Do fungi lurking inside cancers speed their growth?

#32

AFAIK fungi are extremely hard to get rid of. This is not a great news.

Very diverse organism group, and often very tough, but at least it's distinct organisms with distinct characteristics rather than literally the same organism with some of the regulation broken. We have a few chemicals that hurt them while mostly sparing us, and more chemicals which hurt both but them more badly.

Many species of fungus are quite sensitive to high temperatures, which may have been one selection pressure favoring warm-blooded animals. Maybe an artificial fever or even local tissue heating could be enough to tip the balance in favor of the host in some cases.

At the very least it's a fascinating piece of information which is better to be in possession of than not.

Re: Do fungi lurking inside cancers speed their growth?

#33
My introductory biology classes informed me well enough to understand that fungal infections can weaken the body's immune systems, weaken the tissue, or spread themselves over an inflamed area, with unfortunate side-effects of generating pro-growth local environments. Any of these may lead to an incidental increase in cancer growth. What's more, cancer was such a rare occurrence prior to WWI, you wouldn't expect that cancer rates would be directly related to pre-existing fungal flora.

I'm pretty sure dissected tumors have eliminated fungal infections as integral parts of many (if not most) cancers. If it's not integral, fungal is opportunistic and likely unavoidable for most cases. I expect that these conceptual models are what makes these kinds of studies difficult to prove.

Re: Do fungi lurking inside cancers speed their growth?

#34

Sometimes I wonder if we're just giant machines built by microorganisms. It would certainly make an interesting story, along the idea of a robot discovering they were made by somebody else, which I believe has already been explored

Yes, but with a twist: this giant machine worries about its future, its kids, its wealth, its financial assets.

All those are just for satisfying the urge to reproduce.

Re: Do fungi lurking inside cancers speed their growth?

#35

My introductory biology classes informed me well enough to understand that fungal infections can weaken the body's immune systems, weaken the tissue, or spread themselves over an inflamed area, with unfortunate side-effects of generating pro-growth local environments. Any of these may lead to an incidental increase in cancer growth. What's more, cancer was such a rare occurrence prior to WWI, you wouldn't expect that…

> cancer was such a rare occurrence prior to WWI

why do you say that?

Re: Do fungi lurking inside cancers speed their growth?

#36
post #13

Sometimes I wonder if we're just giant machines built by microorganisms. It would certainly make an interesting story, along the idea of a robot discovering they were made by somebody else, which I believe has already been explored

Reminded me: > Animals are something invented by plants to move seeds around. An extremely yang solution to a peculiar problem which they faced. (Terence McKenna)

What about underwater plants? Life started in the water first didn't it?

Re: Do fungi lurking inside cancers speed their growth?

#37

My introductory biology classes informed me well enough to understand that fungal infections can weaken the body's immune systems, weaken the tissue, or spread themselves over an inflamed area, with unfortunate side-effects of generating pro-growth local environments. Any of these may lead to an incidental increase in cancer growth. What's more, cancer was such a rare occurrence prior to WWI, you wouldn't expect that…

Not quibbling with your general point, but was cancer a rare occurrence before WWI on a like-for-like basis? Life expectancy was a great deal lower then - it's gone up by around 30 years (from just over 50 to just over 80) since then.

Re: Do fungi lurking inside cancers speed their growth?

#38
post #27

Earlier quoted context omitted.

Nobody in this thread has read Selfish Gene, apparently. That's the whole point of the book: That genes may as well have invented all of life to propagate themselves. In this context, species conflict is like fleets of world-ships fighting total war.

That’s an interesting SciFi idea: the real world is digital, and digital beings have created a physical world to fight battle via genetic biological machines, which are effectively concrete data structures.

like the scene in Jurassic park

Re: Do fungi lurking inside cancers speed their growth?

#39

My introductory biology classes informed me well enough to understand that fungal infections can weaken the body's immune systems, weaken the tissue, or spread themselves over an inflamed area, with unfortunate side-effects of generating pro-growth local environments. Any of these may lead to an incidental increase in cancer growth. What's more, cancer was such a rare occurrence prior to WWI, you wouldn't expect that…

Not quibbling with your general point, but was cancer a rare occurrence before WWI on a like-for-like basis? Life expectancy was a great deal lower then - it's gone up by around 30 years (from just over 50 to just over 80) since then.

I would theorize that it was less detected prior to WW1, for obvious reasons.

That aside, life expectancy, afaik, includes new born illnesses, childhood illness and so on, and then as adults there were occupational related deaths. Those brought down the average then.

Did those who survived all those risks live as long as we do today? IDK. But there has to be data to figure that out, as the raw life expectancy then v now is likely misleading.

Re: Do fungi lurking inside cancers speed their growth?

#40

Sometimes I wonder if we're just giant machines built by microorganisms. It would certainly make an interesting story, along the idea of a robot discovering they were made by somebody else, which I believe has already been explored

Well, we are biological machines that would not survive without a spectrum of microbes (e.g., gut bacteria). And to your point, kinda, I sometimes wonder if they exist for us, or we exist for them.
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