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Combination of Rapamycin and Acarbose significantly Extends Lifespan

lifespan.io

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Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#31

Post by ehnto »

thornjm wrote: post #24
ck2 wrote: post #5

They've been studying Acarbose for awhile now https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789153/ The problem with a lot of these longevity approaches is they "solve the problem" by reducing energy conversion, like acarbose, pulling people to a baseline and preventing stress adaptations. Great for sitting around. The opposite of that for doing anything athletic, you'd never improve.

There is some evidence that "aerobic exercise" itself produces an equivalent baseline energy deficit without the performance downside. This guy[0] studies total average energy expenditure over time and demonstrates that an athlete undertaking intense regular exercise uses marginally more energy over time than someone sitting on a couch all day. The hypothesis being that the athlete is conserving energy by down-regula…

I have seen this study before, but I can't see how this gentleman's work disproves the huge body of health and fitness research that comes before it. It's an interesting outcome for sure, but the idea that it suggests exercise is a bad weight loss tool doesn't seem to reflect reality. The long term outcome of exercise is a changed body composition, which itself can contribute to changing metabolic rates.

I think it points to an interesting insight, something we have yet to uncover perhaps, but I don't think it disproves that exercise spends energy. Maybe all it's really proving is that we are very efficient at the chosen type of exercise in the study.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#32

Post by jokowueu »

airza wrote: post #30
jokowueu wrote: post #27

Earlier quoted context omitted.

You won't do it at the same doses as cancer treatment protocols . I've been doing rapa for my mood issues stemming from inflammation for some years now and low doses similar to the doses seen in recent studies for age longevity with no apparent side effects .

I don’t know how to ask this neutrally, but how did you (and a doctor?) come to use an anti cancer medication for mood stabilization?

A large amount of rapa was bought during a group buy

It was devided up between people who couldn't afford or get it

To be clear its not specifically an anti cancer med it's an immune suppressant. It targets mtor so it's great for autoimmune disease

The group I belong to specifically are people that have diseases that couldn't be treated either because of financial reasons or because docs wouldn't prescribe meds off label so we resort to such methods .

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#33

Post by ramraj07 »

jokowueu wrote: post #32
airza wrote: post #30

Earlier quoted context omitted.

I don’t know how to ask this neutrally, but how did you (and a doctor?) come to use an anti cancer medication for mood stabilization?

A large amount of rapa was bought during a group buy It was devided up between people who couldn't afford or get it To be clear its not specifically an anti cancer med it's an immune suppressant. It targets mtor so it's great for autoimmune disease The group I belong to specifically are people that have diseases that couldn't be treated either because of financial reasons or because docs wouldn't prescribe meds off l…

So no actual medical professionals involved. Got it. Please start your comments with that, though. You do you, but last I remember I’ve never seen a single person who desperately tried to live long actually live long.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#34

Post by jokowueu »

ramraj07 wrote: post #33
jokowueu wrote: post #32

Earlier quoted context omitted.

A large amount of rapa was bought during a group buy It was devided up between people who couldn't afford or get it To be clear its not specifically an anti cancer med it's an immune suppressant. It targets mtor so it's great for autoimmune disease The group I belong to specifically are people that have diseases that couldn't be treated either because of financial reasons or because docs wouldn't prescribe meds off l…

So no actual medical professionals involved. Got it. Please start your comments with that, though. You do you, but last I remember I’ve never seen a single person who desperately tried to live long actually live long.

I'm not doing it to live long . I have an autoimmune disease that's killing me .

I can't afford the meds so this is the only way I can keep being alive

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#35

Post by elevaet »

nradov wrote: post #11
thebeastie wrote: post #8

Earlier quoted context omitted.

What does that mean, preventing stress adaptations? Does it mean that the body wouldn’t get stronger in training ?

Right. Some of these potential longevity interventions seem to have a catabolic effect. Not a problem if you're a mouse living in a safe, flat lab cage. But problematic for an elderly human at risk of falling down the stairs and breaking a hip due to sarcopenia.

That is really interesting. I hadn't heard that, but it makes a lot of sense.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#36

Post by Loic »

jokowueu wrote: post #34
ramraj07 wrote: post #33

Earlier quoted context omitted.

So no actual medical professionals involved. Got it. Please start your comments with that, though. You do you, but last I remember I’ve never seen a single person who desperately tried to live long actually live long.

I'm not doing it to live long . I have an autoimmune disease that's killing me . I can't afford the meds so this is the only way I can keep being alive

I wish you to be able to have access to it now and in the future.

I have friends with such diseases and wenn I read the line "I can't afford the meds", it always punches me in the belly.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#38

Post by tomohawk »

I get why people are facinated by this sort of research, but pick your favorite nasty person, such as Putin, and consider what it would mean to radically extend their life.

People in in Congress (an oxymoron) would be there even longer as they generally have to die to get kicked out. The longer they're there, the less they care about you and the more they'll care about their long lived fellow travelers.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#40

Post by 29athrowaway »

graderjs wrote: post #20
hericium wrote: post #6

Previous links and discussions on Rapamycin and Metformin: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1] Rapamycin extends life span and health span of male mice and Daphnia magna [2] Drug typically used in cancer therapy emerges as potential anti-aging treatment[3] Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)[4] Metformin for cancer prevention,…

Rapamycin side effects don't look great tho: https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medi…

Better than dying of old age though.
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