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Combination of Rapamycin and Acarbose significantly Extends Lifespan

lifespan.io

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Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#11

Post by nradov »

thebeastie wrote: post #8
ck2 wrote: post #5

They've been studying Acarbose for awhile now https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789153/ The problem with a lot of these longevity approaches is they "solve the problem" by reducing energy conversion, like acarbose, pulling people to a baseline and preventing stress adaptations. Great for sitting around. The opposite of that for doing anything athletic, you'd never improve.

What does that mean, preventing stress adaptations? Does it mean that the body wouldn’t get stronger in training ?

Right. Some of these potential longevity interventions seem to have a catabolic effect. Not a problem if you're a mouse living in a safe, flat lab cage. But problematic for an elderly human at risk of falling down the stairs and breaking a hip due to sarcopenia.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#18

Post by eternityforest »

nradov wrote: post #11
thebeastie wrote: post #8

Earlier quoted context omitted.

What does that mean, preventing stress adaptations? Does it mean that the body wouldn’t get stronger in training ?

Right. Some of these potential longevity interventions seem to have a catabolic effect. Not a problem if you're a mouse living in a safe, flat lab cage. But problematic for an elderly human at risk of falling down the stairs and breaking a hip due to sarcopenia.

Is it strong enough to actually cause that, or is it the kind of thing nonathletes won't notice?

Or is the life extension effect too subtle to be relevant at all outside a flat mousecage?

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#20

Post by graderjs »

hericium wrote: post #6

Previous links and discussions on Rapamycin and Metformin: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1] Rapamycin extends life span and health span of male mice and Daphnia magna [2] Drug typically used in cancer therapy emerges as potential anti-aging treatment[3] Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)[4] Metformin for cancer prevention,…

Rapamycin side effects don't look great tho: https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects

I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medicines"

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