So are you looking to capitalize on your GIS chops? Maybe building location-based apps that are genuinely useful... Or are you trying to figure out how to generate advertising dollars on webby stuff? If it's advertising, I can't help you (I make it a point to never have any ads on any of my sites) -- but if it's GIS, I may. Maybe.
The niche markets I identify are naturally map / data related for a narrow business segment. So yes, I am leveraging my abilities and resources in that field to serve and out-compete others in these spaces. The niche markets are direct sales, not ad based.
Feel free to PM me then.