mypyc is cool and all, but I can't help thinking about how Node just JITs everything automatically without the need for any special steps like this.
That's not Node - that's V8. And it's possible to do the same thing for Python - there's nothing magic about JavaScript compared to Python - it's just a lot of engineering work to do it, which is beyond what this project's scope is. PyPy does it, but not inside standard Python.
It just makes me sad that in a world with multiple high-performance JIT engines (including pypy, for Python itself), the standard Python version that most people use is an interpreter. I know it's largely due to compatibility reasons (C extensions being deeply intertwined with CPython's API).
There is a really important (if not "magic") difference between JavaScript and Python. JS has always (well, since IE added support) been a language with multiple widely-used implementations in the wild, which has prevented the emergence of a third-party package ecosystem which is heavily tied to one particular implementation. Python on the other hand is for a large proportion of the userbase considered CPython, with alternate implementations being second class citizens, despite some truly impressive efforts on the latter.
The fact that packages written in JS are not tied to (or at least work best with) a single implementation is also what made it possible for developers of JS engines to experiment with different implementation approaches, including JIT. While I'm not intimately familiar with writing native extension modules for Node (having dabbled only a little), my understanding is the API surface is much narrower than Python, allowing for changes in the engine that avoid breaking APIs. But there is less need for native modules in JS, because of the presence of JIT in all major engines.