Personally to me the best framework is no framework at all. Instead I use libraries of code and Web Components. The libraries are either my own or some existing ones. Overall writing web front end this way for me is the most natural way. In my personal experience I spend less time creating the web front ends this way comparatively to when using "frameworks". No "compiling" is needed either, other then optional minimi…
Let's have a look at this "compiled" JS. Here's an snippet from the volume slider in his example:
function b() { v = W4(this.value), h(0, v) }
I understand that this is "compiled" - but really it's not - it's EcmaScript. If I wrote code like that, I'd get fired.