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Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

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Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#141

Post by crypticlizard »

jonathan-adly wrote: post #87

Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive e…

Could you comment on if you think there is a natural analogue out there? Even if less effective? For example a quick google search led me to this: https://www.nutraingredients-usa.com/Article/2017/12/01/Ashw...

Which is suggesting Ashwagandha might a candidate for Rapamycin and Metformin mimcry.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#142

Post by tootie »

coolstepa wrote: post #135

There is a super interesting Radiolab episode on the scientist who discovered Rapamycin, and how he himself was taking it to combat colon cancer. It's really good, and the ending has you quite puzzled. https://radiolab.org/episodes/dirty-drug-and-ice-cream-tub

Yeah, the story is absolutely bananas. Not just the personal effort of the scientist, but what in the world even made them think to try any of this. The "Rapa" in the name is from Rapa Nui because this was a chemical found in a random soil sample from Easter Island. This deserves some conspiracy theories.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#143

Post by wobbleblob »

orangepurple wrote: post #4

The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.

Ages ago, I had a colleague who was deeply into hacking of his mTOR pathway. Among other things, this included a permanent calorie deficit and removal of all protein from his diet.

I don't know if he's still alive. Maybe it was working a bit too well, I recall he looked like an extremely tall 13 year old with anorexia.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#144

Post by adrian_b »

BiteCode_dev wrote: post #103
jonathan-adly wrote: post #87

Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive e…

What makes me scared about this is that it's immunosuppressive. The immune system is a very important part of the human body, and I worry that taking it could have terrible health impact after years of acting on your body lines of defense. What can you tell me about it?

According to the abstract of the article, its effects, at least in that form of using it, were not immunosuppresive.

On the contrary, the protection of the intestine to aging effects was due to increased autophagy in the intestinal cells, which eliminated the defective cells, and by increased levels of antimicrobial lysozyme, and these effects persisted long after the initial treatment ended.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#145

Post by tepitoperrito »

BiteCode_dev wrote: post #103
jonathan-adly wrote: post #87

Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive e…

What makes me scared about this is that it's immunosuppressive. The immune system is a very important part of the human body, and I worry that taking it could have terrible health impact after years of acting on your body lines of defense. What can you tell me about it?

There's a study on pubmed that suggests it is more immunomodulatory in action than suppressive. I'll update this if I find the link.

Edit: it's an opinion article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#146

Post by vorpalhex »

boredemployee wrote: post #19

genuine question: why would someone want to live longer than the average? Edit: I ask because I personally don't see a reason to stay alive while people I love are dying, I don't see a reason to stay alive in an already fucked up planet, while we empty all the resources, etc. But you guys are so smart, intelligent and clever, why even bother.

If I could have a thousand years to read and study deeply and just write and think, I would take it.

Yes my loved ones will die and that will make me sad. I'll grieve and move on. My life is not theirs - their death does not mean an end to what I am doing.

Flip the problem. If you could bestow a friend/family member with a thousand years, even knowing you will die, would you?

One of the ancient greek prophets declared the apocalypse would happen in 9 generations. She was quite wrong. Most doomsday prophets are (well, probably all but the last one).

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#147

Post by deltasevennine »

CrispCas13 wrote: post #55
orangepurple wrote: post #4

The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.

As added information: metformin, a common anti-diabetic drug, is a inhibitor of mTOR. It potential adverse effects are less severe than rapamycin but are still significant. Specifically, long term usage can cause renal damage. Its mechanism of action has yet to be fully elucidated.

Can you source this? I believe you and I wanted to look into it. I googled this and I did not find anything explicitly saying renal damage. I did find many articles saying it's not safe to take if you already have renal disease but nothing saying that it causes it.

I even found articles that says it doesn't cause renal failure. I'm sure what you said is some real study just not popularized yet.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#148

Post by ltbarcly3 »

phkahler wrote: post #72
rdedev wrote: post #67

After reading the following article I've tempered my expectations from ramapycin https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-... The drug has been known for a long time but human trials always seems elusive

>> The drug has been known for a long time but human trials always seems elusive Human trials of this will likely never happen. At least not publicly.

Why is that? Literally nobody will do the research in any country in the world because the Illuminati are everywhere?

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#149

Post by ipaddr »

SketchySeaBeast wrote: post #120
arcticfox wrote: post #115

Earlier quoted context omitted.

That is a very shallow perspective. Fasting causes large, measurable phase changes in cellular function (eg autophagy). You can question whether it actually works or not, but there's a very plausible mechanism for why it would work that isn't simply related to calories-in-calories-out weight loss.

I think it's fair to say that we don't have to do something just because there's a plausible mechanism for a benefit. If there are clear and obvious health benefits that are far beyond what you see with a regular calorically restricted diet, I haven't heard them well explained.

https://www.hopkinsmedicine.org/health/wellness-and-preventi....

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#150

Post by ltbarcly3 »

boredemployee wrote: post #19

genuine question: why would someone want to live longer than the average? Edit: I ask because I personally don't see a reason to stay alive while people I love are dying, I don't see a reason to stay alive in an already fucked up planet, while we empty all the resources, etc. But you guys are so smart, intelligent and clever, why even bother.

The people you love can take it too?
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