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Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

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81–90 of 228 posts

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#81
post #63

I'm a month into taking rapa and already I feel like it's having a noticeable effect. I'm curious what others on this threads dosage looks like. If you prefer to keep it private, you can email me directly (my email is on my profile). I'm currently taking 2mg once a week on my rest day; I started with 1mg and after 1 month added another MG. I'll continue each month until I reach 8MG once a week, which is the dosage th…

What's NMN?

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#82
post #74

FYI one study shows that rapamycin increases amyloid-beta protein plaques in the brains of mice. https://neurosciencenews.com/rapamycin-amyloid-beta-20770/

All of the original data around amloyd-beta protein data was faked. A lot of it was even just outright photoshopped. https://www.science.org/content/blog-post/faked-beta-amyloid...

FFS. I forgot about that.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#83
post #81
post #63

I'm a month into taking rapa and already I feel like it's having a noticeable effect. I'm curious what others on this threads dosage looks like. If you prefer to keep it private, you can email me directly (my email is on my profile). I'm currently taking 2mg once a week on my rest day; I started with 1mg and after 1 month added another MG. I'll continue each month until I reach 8MG once a week, which is the dosage th…

What's NMN?

Nicotinamide Mononucleotide, an unregulated supplement.

Note also:

> We found that, when data from all organisms studied were combined for each compound, aspirin resulted in the highest percent increase in average lifespan (52.01%), followed by minocycline (27.30%), N-acetyl cysteine (17.93%), nordihydroguaiaretic acid (17.65%) and rapamycin (15.66%), in average.[0]

Though I'd consider whether flies and worms are good models for your human self.

0: https://pubmed.ncbi.nlm.nih.gov/34687363/

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#85
post #29

When somebody asks about what is the next big thing, I always think on anti-aging. If you think that you don’t want to live forever, imagine that today when you arrive home you find a note saying that you will die exactly 1531[^1] days from today. How would you feel? With that said, I would stay away from miracle drugs, because no two human beings have the same physiology. But that’s not an unsolvable problem. [^1]:…

I would argue that a miracle anti aging drug would work well for the majority of the population, much like NSAIDs work well for the majority of the population. Bonus points for being cheap and easy to synthesize.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#86
There seems to be a growing trend of generally healthy people looking for drugs/supplements to provide marginal improvements. I can't help thinking it's a sign of a vacuous and unfulfilling life. Instead of spending time and money on drugs to increase your life span, why not spend that time/money on actually living your life? I think this probably comes down to the general boredom that comes from not having a family and not having enough time off work to do anything else worthwhile.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#87
Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive effects.

Anyway, I am tinkering with something in that space - feel free to reach out if you want explore being a co-founder. (email in about)

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#88
post #15

What's the latest on bloodboys? That is : periodic blood transfusion from healthy young vegan donor. It works very well. Rejuvenates ancient billionaires. Surely it's superpopular among the oligarchs. Probably not the kind of thing you want in the news (vampires!). The technical term is Parabiosis . These guys offer the service : https://www.ambrosiaplasma.com/

It's so strange to me that is is legal in the US when prostitution isn't(in most states).

Not that I think prostitution should be illegal, but it's basically the same thing.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#90
post #29

When somebody asks about what is the next big thing, I always think on anti-aging. If you think that you don’t want to live forever, imagine that today when you arrive home you find a note saying that you will die exactly 1531[^1] days from today. How would you feel? With that said, I would stay away from miracle drugs, because no two human beings have the same physiology. But that’s not an unsolvable problem. [^1]:…

Honestly, at peace lol. I don't really care about living.

My primary desire for living atm is keeping my family safe, providing for them, etc. Beyond that, i am living just because i am - and i enjoy life as much as i don't want to _not_ enjoy time i'm here anyway.

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