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Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

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1–10 of 228 posts

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#4
The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#5
post #2

There was an in depth discussion about this drug with a longevity researcher on a recent episode of the Tim Ferriss podcast, in case anyone wants to dive deeper.

> a longevity researcher

Probably Peter Attia?

There's also some free to read review articles (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/). No idea about the quality of the journal Aging or the field in general, though.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#6

The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.

> ... to simply stop consuming nutrients for extended periods of time

That is not simple for most people.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#7
post #6

The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.

> ... to simply stop consuming nutrients for extended periods of time That is not simple for most people.

simple != easy

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#9
post #5
post #2

There was an in depth discussion about this drug with a longevity researcher on a recent episode of the Tim Ferriss podcast, in case anyone wants to dive deeper.

> a longevity researcher Probably Peter Attia? There's also some free to read review articles ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/ ). No idea about the quality of the journal Aging or the field in general, though.

No, Matt Kaeberlein-- here's the transcript of the episode.

https://tim.blog/2022/07/30/matt-kaeberlein-life-extension-t...

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#10
post #6

The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.

> ... to simply stop consuming nutrients for extended periods of time That is not simple for most people.

I think they meant fasting.
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