Psychedelic drugs take on depression
nature.com
Psychedelic drugs take on depression
1–10 of 118 posts
Re: Psychedelic drugs take on depression
#2They should not be lumping ketamine in with all the other psychedelics which act on the serotonin 2A receptor. I’m hesitant to say ketamine is a psychedelic at all.
Regardless, I find .25 mg of Klonopin can get rid of my depression as well, they’ve known for a long time that depression has a strong linked glutamate excitation in certain parts of the brain.
Re: Psychedelic drugs take on depression
#3Ketamine is a magical drug, I've told this story a hundred times on HN but it cured my depression overnight.
I was given a large hit of it by a doctor after a horrible accident, I went into a K-hole and had a spiritual experience, but even more profound was the effect it had for 4 to 6 months after.
It was like a veil had been lifted from my mind, the simplest pleasures of life made me happy, like smelling fresh coffee or feeling the sun on my skin. I had been living in misery for decades and suddenly I was awake and lucid and happy.
Re: Psychedelic drugs take on depression
#4Ketamine is a magical drug, I've told this story a hundred times on HN but it cured my depression overnight. I was given a large hit of it by a doctor after a horrible accident, I went into a K-hole and had a spiritual experience, but even more profound was the effect it had for 4 to 6 months after. It was like a veil had been lifted from my mind, the simplest pleasures of life made me happy, like smelling fresh coff…
Oh I’ve had that experience, and I’m just bipolar.
Ketamine has been known to trigger hypomania and mania in patients.
https://pubmed.ncbi.nlm.nih.gov/33587793/
10 mg of Prozac will do the same thing to me, but that’s just my genetics.
Re: Psychedelic drugs take on depression
#5Ketamine is a magical drug, I've told this story a hundred times on HN but it cured my depression overnight. I was given a large hit of it by a doctor after a horrible accident, I went into a K-hole and had a spiritual experience, but even more profound was the effect it had for 4 to 6 months after. It was like a veil had been lifted from my mind, the simplest pleasures of life made me happy, like smelling fresh coff…
It replaced my lifelong fear (terror?) of death with what I can honestly say is now curiosity. You can experience only so many deaths in your mind before you learn to be comfortable with the idea.
Re: Psychedelic drugs take on depression
#6Ketamine is a magical drug, I've told this story a hundred times on HN but it cured my depression overnight. I was given a large hit of it by a doctor after a horrible accident, I went into a K-hole and had a spiritual experience, but even more profound was the effect it had for 4 to 6 months after. It was like a veil had been lifted from my mind, the simplest pleasures of life made me happy, like smelling fresh coff…
Seconded. For me however, its a monthly treatment for an hour in an office run by an anesthesiologist. The difference is night and day compared to any SSRI, SNRI, or TCA I've ever been on. Exempting the 3-4 hours post treatment, no ill side effects either.
Re: Psychedelic drugs take on depression
#7Ketamine is a magical drug, I've told this story a hundred times on HN but it cured my depression overnight. I was given a large hit of it by a doctor after a horrible accident, I went into a K-hole and had a spiritual experience, but even more profound was the effect it had for 4 to 6 months after. It was like a veil had been lifted from my mind, the simplest pleasures of life made me happy, like smelling fresh coff…
Regular SSRI had the same effect for me.
Re: Psychedelic drugs take on depression
#8Ketamine is a magical drug, I've told this story a hundred times on HN but it cured my depression overnight. I was given a large hit of it by a doctor after a horrible accident, I went into a K-hole and had a spiritual experience, but even more profound was the effect it had for 4 to 6 months after. It was like a veil had been lifted from my mind, the simplest pleasures of life made me happy, like smelling fresh coff…
Oh I’ve had that experience, and I’m just bipolar. Ketamine has been known to trigger hypomania and mania in patients. https://pubmed.ncbi.nlm.nih.gov/33587793/ 10 mg of Prozac will do the same thing to me, but that’s just my genetics.
I don't think that was it for me, though I see the parallels. I just wasn't miserable, the examples I gave were the highlights but really the core of it was that life felt tolerable. Looking at the hypomania symptoms I didn't exhibit any, beside the elevated mood.
Re: Psychedelic drugs take on depression
#9The frequency of these kind of posts followed by anecdotes about how it worked for the commenter (who I believe btw) makes me a little uneasy. Somewhere buried in the discussion eventually is a comment from a relevant professional urging caution in interpreting and reacting to these news reports and anecdotes. Now with something as serious as this I would not at all object to such cautions being placed a bit more prominently. This isn’t reckless use of goto being discussed but something much more serious. Anyway, I just wanted to get that off my chest. Perhaps it’s just me, don’t take it as a holier than thou attitude.
Re: Psychedelic drugs take on depression
#10Psychedelics are illegal not because they create hallucinations but rather because they help break down the hallucinations we have about the world. In the land of the blind, the one eyed man is a hallucinating idiot.