There is stunningly little literature on any R&D in conventional freight rail transport, something I discovered when looking for any published research some months back.
High-speed rail, yes. Regular old freight, no.
Contrast this with autonomous and electrified trucking as alternatives, with which rail could offer considerable synergies.
I'd suspect that break-bulk, trainset assembly and disassembly, and routing might all offer opportunities.
But ... nada.
I suspect other modalities within the transport sector might be similar, notably ocean shipping.