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A lab pursuing de-extinction of the thylacine partners with a genetics company

unimelb.edu.au

41–50 of 60 posts

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#41
post #22

I wonder, have they asked the people of Tasmania if they want it back? It's Jurassic Park writ small.

De-extinction doesn't necessarily mean they will release animals back into the wild. Presumably a portion of animal behaviour is learned and passed down from the previous generation. Animals produced by de-extinction will be lacking these behaviours and perhaps best off in captivity.

yes, this is something most ppl get wrong.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#42
post #22

I wonder, have they asked the people of Tasmania if they want it back? It's Jurassic Park writ small.

De-extinction doesn't necessarily mean they will release animals back into the wild. Presumably a portion of animal behaviour is learned and passed down from the previous generation. Animals produced by de-extinction will be lacking these behaviours and perhaps best off in captivity.

It's too bad it would be highly unethical to run experiments with humans in tabula rasa environments. It would be really neat to see what different social behaviors emerge.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#43

Earlier quoted context omitted.

Why?

My guess: if non-genetic heritable elements -- epigenetics (such as modifications to DNA) -- are necessary for proper development, then the DNA sequence alone will not be enough to develop thylacines. (There are caveats, notably that some modifications can be inferred). However, the scientists will also be experimenting with gestation and creating embryos from modified cells, so whether epigenetics specifically is a…

This is a really great point. I want very much their effort to succeed, but I suspect epigenetic is so important for higher organisms that the chances of this working are rather low.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#44

“We can now take the giant leaps..." says Professor Pask of the Thylacine Integrated Genetic Restoration Research (TIGRR) Lab. Which is a lot more accurate than the article headline, which says that they _have already_ taken a 'giant leap'. I expect such exaggeration and overstatement from mainstream news sources; I suppose I should not be surprised to see it coming from a university website.

At least they didn’t say quantum leap…

Or exponential leap.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#45

If they are successful, how do they navigate challenges related to inbreeding given what is likely to be a very small population of adult animals to work with?

Since the thylacine has been extinct for less than a century, they appear to be hoping that there's enough genetic diversity in modern preserved samples to eventually produce a diverse population. Even with a highly limited population, if you strictly control which pairs breed and aggressively pair the ones that are least related, you only need an initial population of like 16 or something to eventually reach a state where you have a large breeding population where most individuals don't share grandparents, at which point you can let nature take over.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#46

Earlier quoted context omitted.

Except that in general the "rediscovery" isn't something dramatic -- it's just a systematist in a lab looking at an animal known by many and realizing that it is the same species as fossilized/preserved specimens thought to be extinct rather than a common related species. That's quite different from finding a thylacine, an animal that couldn't be confused with anything else.

This seems like a very inaccurate summary of the examples given in that article.

Bermuda Petrel -- there are many nearly identical petrels, exactly the same to non-experts.

Chacoan Peccary -- There are many wild pigs.

Coelacanth -- Maybe the only real example of a "rediscovered species". But that's only because we know the oceans far less than we know the land.

Lord Howe Island Stick Insect -- You've probably seen a stick insect like this yourself even if it is genetically different.

La Palma Giant Lizard -- Same genus as Gallotia, a very common lizard on the Canary islands.

Takahe -- It's the same genus as the swamp hen. To an non-expert, they are the same.

Cuban Solenodon -- it looks like a common shrew to non-experts.

New Caledonian Crested Gecko -- It's a geko.

New Holland Mouse -- it's a mouse (not a marsupial, despite being native to Australia).

Giant Palouse Earthworm -- It's an earthworm, although larger than normal.

Large-Billed Reed-Warbler -- same genus as many other warblers, exactly the same to non-experts who don't measure the bill.

Laotian Rock Rat -- It actually is of a unique genus, so more interesting than most of these examples, but still, it's a rodent not that different to the average person than other rodents.

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#48
post #15

Earlier quoted context omitted.

There are periodic sightings of them. Although not with high enough confidence or documentation to say definitely, "They are still out there".

It's not plausible that such a large animal can have a self-sustaining population in the wild, and not be properly detected by the scientific community for 100 years.

In 1910 someone tried to introduce moose into a remote corner of New Zealand [1]. They haven't been seen since 1952, but seem to still be out there, as hair was found in 2002. If things as big as moose can hide a self-sustaining population in a small corner of New Zealand, thylacines could plausibly hide in Australia or Tasmania.

[1] https://en.wikipedia.org/wiki/Moose#New_Zealand

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#49
> Australia’s only marsupial apex predator

This is only true if you just count recent history. It's the largest to survive the megafauna extinctions after humans arrived, and was out-competed by the non-marsupial dingo after that was introduced much later.

The "marsupial lion" thylacoleo carnifex (extinct ~35k years ago) was much bigger and more powerful, and "had the strongest bite of any known mammal, living or extinct". https://en.wikipedia.org/wiki/Thylacoleo_carnifex

Australia had tons of much larger herbivores too: https://en.wikipedia.org/wiki/Australian_megafauna#Extinct_A...

Re: A lab pursuing de-extinction of the thylacine partners with a genetics company

#50

If they are successful, how do they navigate challenges related to inbreeding given what is likely to be a very small population of adult animals to work with?

Random mutagenesis eg radiation could be used to introduce diversity.
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