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New antibody neutralizes all known SARS-CoV-2 variants in lab tests

hms.harvard.edu

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Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#171

Post by tsimionescu »

peyton wrote: post #129
tsimionescu wrote: post #128

Earlier quoted context omitted.

You're going in circles. We were discussing a vaccine that was discovered with most funding coming from charities (B&M Gates foundation) or the state (NIH), and some by Pfizer. But, Pfizer gets to keep 100% of the results of this research. Now, if by "development" you mean the cost of mass manufacturing and marketing the substance, then every company that wants to manufacture it can find their own, which will be paye…

Development means clinical testing, preparation and submission of applications for FDA approval, as well as design of production processes for new drugs. Here’s an accessible overview from the CBO: https://www.cbo.gov/publication/57126

How is this relevant to the topic at hand, of licensing the base molecule (not the finished drug) to multiple companies?

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#172

Post by qbasic_forever »

lbeltrame wrote: post #142
qbasic_forever wrote: post #88

Earlier quoted context omitted.

Covid antibodies, even vaccine induced ones, don't stick around for much more than 3-6 months. Whatever natural immunity you got nearly 3 years ago is long since useless. You're either getting lucky or an asymptomatic case and not knowing it. edit: Since you're unvaccinated, go get a covid antibody test and check for yourself how good (or terrible) your immunity is to the virus. You can take either one, the S type or…

> Whatever natural immunity you got nearly 3 years ago is long since useless This is factually incorrect. You don't have perhaps protection against infection , nor probably symptomatic disease , but there is working natural immunity, in the form of immune memory and cell based immunity (T lymphocytes). That is far, far more resistant to variants than humoral (antibody based) immunity, mainly because only antibodies n…

Where is the T cell immunity? People are on their fourth and fifth infections now. If there were strong T cell protection we wouldn't see constant reinfection.

T cells will save us has been a big coping strategy from people trying to claim the pandemic is over too soon. Hucksters like Monica Ghandi have been saying T cells will save us for years now.

When... when will it happen I ask. Over a million dead bodies and people still racking up infections. Back up to an average of 500 people dying a day even in our summer lull right now, and it's climbing again.

Where is the T cell protection?

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#173

Post by psychphysic »

mnw21cam wrote: post #111
psychphysic wrote: post #65

Earlier quoted context omitted.

Unless you're licking buttons on the subway, how could you possibly be getting exposed to that many different strains? For what it's worth adults get the flu about every 5 years[0]. It's not till we get elderly that we can start catching the same or similar strains more frequently. Similarly with the cold, which are coronaviruses like COVID just lead to less lasting immunity. Long story short. This kind of research w…

> Similarly with the cold, which are coronaviruses like COVID just lead to less lasting immunity. This common knowledge needs to die. "Well over 200 virus strains are implicated in causing the common cold, with rhinoviruses, coronaviruses, adenoviruses and enteroviruses being the most common."[0] [0] https://en.wikipedia.org/wiki/Common_cold referencing a web page that has gone missing and has re-appeared as https://…

No post body was provided.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#174

Post by psychphysic »

krageon wrote: post #113
psychphysic wrote: post #65

Earlier quoted context omitted.

Unless you're licking buttons on the subway, how could you possibly be getting exposed to that many different strains? For what it's worth adults get the flu about every 5 years[0]. It's not till we get elderly that we can start catching the same or similar strains more frequently. Similarly with the cold, which are coronaviruses like COVID just lead to less lasting immunity. Long story short. This kind of research w…

The quoted paper doesn't support what you say. It also doesn't demonstrate a difference in the elderly. Given that, I'm inclined to take the rest of this post with a grain of salt and I think every other reader should do the same.

No post body was provided.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#175

Post by HWR_14 »

jjcon wrote: post #87
HWR_14 wrote: post #44

Earlier quoted context omitted.

> by giving human populations such artificial resistances (non-live vaccines) we run the risk of selecting for viruses that are even harder for even our own immune systems to detect and destroy I can put your fears to bed. That shouldn't happen. How vaccines work is they teach a very specific signature to our bodies so it can be destroyed as soon as it appears. . Therefore, any selection pressure would just be to not…

Are you saying that because the number of possible signatures is so vast and the vaccines so specific, even if they get slightly broader it isn’t going to make things worse because in the grand scale of things we aren’t really walling too much off?

I'm saying that at most using the vaccine will cause a virus to evolve that it evades the vaccine. It won't get any other supervirus properties, become worse, or otherwise change. The concern with using antibiotics (for instance) is that a bacteria becoming immune to one becomes more resistant to all and it's hard to generate new antibiotics. On the other hand, with the vaccine, you just might need a booster with a different signature. There's no "broadening". It's just different.

So, a vaccine's immunity might not last forever. And?

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#176

Post by smileysteve »

HWR_14 wrote: post #175
jjcon wrote: post #87

Earlier quoted context omitted.

Are you saying that because the number of possible signatures is so vast and the vaccines so specific, even if they get slightly broader it isn’t going to make things worse because in the grand scale of things we aren’t really walling too much off?

I'm saying that at most using the vaccine will cause a virus to evolve that it evades the vaccine. It won't get any other supervirus properties, become worse, or otherwise change. The concern with using antibiotics (for instance) is that a bacteria becoming immune to one becomes more resistant to all and it's hard to generate new antibiotics. On the other hand, with the vaccine, you just might need a booster with a d…

To the contrary, viruses are not intelligent, when mutations happen at random, the best way to prevent mutation is to prevent infection and length of infection.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#177

Post by d0mine »

maegul wrote: post #31
robbiep wrote: post #20

Earlier quoted context omitted.

Evolution is climbing mount improbable. And natural selection (even in the face of in this case intelligently designed selectors) funnels organisms into potential dead ends which they can’t evolve out of - they’ve gone up the ‘north face’ and in order to reach fitness in the face of their selectors, they actually need to be on a completely different mountain. An antibody that dead ends all current evolutionary trends…

So, from the article: > Once the virus has bound to ACE2, it must complete a final step: fusing its outer membrane with the membrane of our cells. This throws the door open to infection. Using a novel live-cell imaging platform, Alex Kreutzberger, HMS instructor in pediatrics at Boston Children’s, and Tomas Kirchhausen, professor of cell biology in the Blavatnik Institute at HMS and professor of pediatrics at Boston…

If you never see bullet holes in some part of a fuselage, it likely means those planes that do have holes in those places never return home that they are vulnerable area which require more armor. https://en.wikipedia.org/wiki/Abraham_Wald

If you don't see some part of a virus ever mutate, it marks a vulnerable location.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#178

Post by xupybd »

criddell wrote: post #143
xupybd wrote: post #57

Can we please have this sort of research for the common cold and flu please. I hate flu season, I'm normally sick three of four times a winter. I get really sick at least once a year. I'd love to avoid that.

Have you noticed if getting a flu shot makes a difference for you?

It normally means I recover about a week earlier when I get the flu. So instead of two weeks down it's a little under one. But I don't know for sure that's not just coincidence.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#179

Post by johnchristopher »

jjcon wrote: post #86
johnchristopher wrote: post #39

Earlier quoted context omitted.

> by giving human populations such artificial resistances (non-live vaccines) we run the risk of selecting for viruses that are even harder for even our own immune systems to detect and destroy That'd be a valid question if we didn't ready have non-live vaccines with very good proven track records for polio, hepatitis, the flu, etc. > Current Covid strains don’t seem all that bad, basically everyone I know has been i…

Where did I deny Covid? I simply asked if stronger vaccines could lead to stronger viruses and make things worse than they already are

No, you did not simply ask that. You also said Covid is now not that bad and implied it's okay to be infected since everyone you know has been infected now.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#180

Post by jjcon »

robbiep wrote: post #169
jjcon wrote: post #164

Earlier quoted context omitted.

So it is 100% certainty then? Not just very unlikely? The quantification of certainty among experts is what I am wondering

Quoted post unavailable.

Quit being so hostile, if you are not interested in discussion I would recommend not spending time on discussion boards.

You first spoke as if it was an absolute certainty ("This is basic evolutionary theory") and now are saying, "all of the normal caveats apply" which is exactly what I was getting at in my OP thread. The "normal caveats"/edge cases are exactly what this whole discussion is about. Clearly we are speaking past one another, I apologize for my role in whatever went wrong here.

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