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New antibody neutralizes all known SARS-CoV-2 variants in lab tests

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Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#111

Post by mnw21cam »

psychphysic wrote: post #65
xupybd wrote: post #57

Can we please have this sort of research for the common cold and flu please. I hate flu season, I'm normally sick three of four times a winter. I get really sick at least once a year. I'd love to avoid that.

Unless you're licking buttons on the subway, how could you possibly be getting exposed to that many different strains? For what it's worth adults get the flu about every 5 years[0]. It's not till we get elderly that we can start catching the same or similar strains more frequently. Similarly with the cold, which are coronaviruses like COVID just lead to less lasting immunity. Long story short. This kind of research w…

> Similarly with the cold, which are coronaviruses like COVID just lead to less lasting immunity.

This common knowledge needs to die.

"Well over 200 virus strains are implicated in causing the common cold, with rhinoviruses, coronaviruses, adenoviruses and enteroviruses being the most common."[0]

[0] https://en.wikipedia.org/wiki/Common_cold referencing a web page that has gone missing and has re-appeared as https://www.cdc.gov/features/rhinoviruses/ with slightly different wording.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#112

Post by mnw21cam »

inopinatus wrote: post #95
jjcon wrote: post #7

Can anyone with more knowledge on this topic than me (I’m no expert) assuage my fears: by giving human populations such artificial resistances (non-live vaccines) we run the risk of selecting for viruses that are even harder for even our own immune systems to detect and destroy. Current Covid strains don’t seem all that bad, basically everyone I know has been infected now. Might we run the risk of making things worse…

> Current Covid strains don’t seem all that bad, basically everyone I know has been infected now The first observation is false, the second, very far from universal.

Indeed, there's still plenty of people ending up in hospital because of covid, including me three months ago.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#113

Post by krageon »

psychphysic wrote: post #65
xupybd wrote: post #57

Can we please have this sort of research for the common cold and flu please. I hate flu season, I'm normally sick three of four times a winter. I get really sick at least once a year. I'd love to avoid that.

Unless you're licking buttons on the subway, how could you possibly be getting exposed to that many different strains? For what it's worth adults get the flu about every 5 years[0]. It's not till we get elderly that we can start catching the same or similar strains more frequently. Similarly with the cold, which are coronaviruses like COVID just lead to less lasting immunity. Long story short. This kind of research w…

The quoted paper doesn't support what you say. It also doesn't demonstrate a difference in the elderly. Given that, I'm inclined to take the rest of this post with a grain of salt and I think every other reader should do the same.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#115

Post by krageon »

eggy wrote: post #84

Quoted post unavailable.

You are not an expert and have only anecdotal evidence. Someone might read your post and assume that your advice is healthy to follow, while it flies in the face of actual medical advice. As such, your post is actively harmful to other people.

It is also not intellectually interesting, as it is just a rehash of what is essentially facebook COVID reporting.

At the very least you should not try to infect others with your harmful information. It is very antisocial to do so.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#116

Post by coldtea »

peyton wrote: post #94
ChuckMcM wrote: post #69

Earlier quoted context omitted.

Perhaps. If you feel you have an understanding of the system I'm criticizing, why not help me understand why it has to be this way? I get it if you don't have the time or inclination to do so, but surprisingly I'm actually really open to learning new things and it would be appreciated not only by me but by other people reading your comments if you could explain the current system, perhaps other systems that have been…

Yeah. This is the only system ever found that reliably turns out 30–40 new drugs a year. Others like USSR’s and Japan’s didn’t.

How many of those are any good and not snake-oil crap?

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#117

Post by rastignack »

mellavora wrote: post #96
xupybd wrote: post #57

Can we please have this sort of research for the common cold and flu please. I hate flu season, I'm normally sick three of four times a winter. I get really sick at least once a year. I'd love to avoid that.

My wife used to be the same, got 3-5 colds/winter. Started wearing N95 masks with Covid and hasn't had a cold since. Basic hygiene really helps. Though you might have unavoidable exposure (workplace, commute, etc) which increases your risk.

Under solicitation of the immune system can make you more vulnerable to some viruses though, if you finally get infected.

Avoiding colds might not be as beneficial as we think.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#118

Post by pbhjpbhj »

retcore wrote: post #79
ChuckMcM wrote: post #75

Earlier quoted context omitted.

Actually patents themselves don't have arbitrary length. They are 20 years and then done[1]. That said, there are patents on refinements or add-ons that come later, and so sometimes the patent expires but it has been replaced by a new way that is even better. There is a scheme in the pharmacy market for shifting patents to prevent generics from being produced, that scheme would be outlawed if we had the right mix of…

The problem starts with the time between patent award and regulatory approval limiting the commercial exclusivity. This has driven big pharma to patent manufacturing processes instead of the compounds. If I understand it correctly from memory the Ritalin availability crisis was a example of process patent reengineering. Edit: was not is.

There is a system called supplementary protection certificates (SPCs) that gives an extension you the monopoly period to account for regulatory approval periods.

https://en.wikipedia.org/wiki/Supplementary_protection_certi... (I haven't checked this link).

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#119

Post by peyton »

teaearlgraycold wrote: post #101
peyton wrote: post #99

Earlier quoted context omitted.

What about development?

Basically I’m saying they should make a finished solution but leave distribution and full scale manufacturing to private industry. Not because private will do that part better, but because at that point there’s not much need to use taxes to finish the job. What drug manufacturer wouldn’t want the contract to exclusively sell an already developed product? All they need to do is follow FDA regulations and pricing.

“Making a finished solution” is the really, really expensive part. How does the government allocate limited resources in your model?

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#120

Post by johnchristopher »

ehvatum wrote: post #89
johnchristopher wrote: post #39

Earlier quoted context omitted.

> by giving human populations such artificial resistances (non-live vaccines) we run the risk of selecting for viruses that are even harder for even our own immune systems to detect and destroy That'd be a valid question if we didn't ready have non-live vaccines with very good proven track records for polio, hepatitis, the flu, etc. > Current Covid strains don’t seem all that bad, basically everyone I know has been i…

To be fair, you are stigmatizing someone for offering a correct observation (that the successive COVID variants have proven less debilitating and deadly) and for asking a question that must be on many people’s minds: can monoclonal antibody administration promote resistance analogous to bacterial antibiotic resistance? Be aware that live virus vaccines are certainly not monoclonal antibody injections. As well, rather…

> To be fair, you are stigmatizing someone for offering a correct observation (that the successive COVID variants have proven less debilitating and deadly) and for asking a question that must be on many people’s minds: can monoclonal antibody administration promote resistance analogous to bacterial antibiotic resistance?

No, I am singling out another comment which spreads doubts and denial by hiding them among good faith arguments. For instance:

> (that the successive COVID variants have proven less debilitating and deadly)

Doesn't mean it's not debilitating and deadly.

> basically everyone I know has been infected now.

And I haven't and neither my best friend nor my parents did. But my brother did and another friend did. Guess which one is complaining 6 months later of symptoms that are not going away ?

> As well, rather than spending your mental energy developing excuses to dismiss, why not think on the subject at hand? You should wonder why this mouse model produces broadly neutralizing antibodies in response to COVID spike proteins while the human immune system does not.

> That’s a bit interesting to the subject of COVID, isn’t it? Certainly more so than windmills and politics.

I believe Covid was and is still dangerous and not to be taken lightly because "most people I know has been infected and successive strains are less deadly" (the last one being also dodgy since it might as well be less deadly for an individual but more deadly for a population if it infects much more people, anyway...). That's as worthy to discuss as the core of the submission is.

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