Earlier quoted context omitted.
I recently tried Guix which is somewhat similar to Nix in theory. While I loved the idea I did not love dealing with cryptic problems resulting from it. For example I ran into an issue where one R package would only work properly if I installed other packages in a specific order, doing an update though could mess up that order breaking the package. Later updates to R broke support for certain things entirely that I d…
I mean if you don't want to fiddle with it I really don't get why you would choose Guix to test drive this way of managing your packages. It's the way less mature and less supported Nix.
Unlike R in Nix, Guix does not just automatically wrap R packages, which would lead to build and runtime errors. I would not use R from Nix.